Molecules 2011, 16(3), 2375-2390; doi:10.3390/molecules16032375
Article

Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis

1 Department of Epidemiology and Public Health, University of Miami Miller School of Medicine and Sylvester Cancer Center, Miami, Florida 33136, USA 2 Marucci Center for Blueberry Cranberry Research, Rutgers University, Chatsworth, New Jersey 08019, USA 3 Department of Pathology, The Ohio State University, Columbus, Ohio 43240, USA
* Author to whom correspondence should be addressed.
Received: 28 January 2011; in revised form: 8 March 2011 / Accepted: 10 March 2011 / Published: 11 March 2011
(This article belongs to the Special Issue Tannins)
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Abstract: Cranberries are rich in bioactive constituents purported to enhance immune function, improve urinary tract health, reduce cardiovascular disease and more recently, inhibit cancer in preclinical models. However, identification of the cranberry constituents with the strongest cancer inhibitory potential and the mechanism associated with cancer inhibition by cranberries remains to be elucidated. This study investigated the ability of a proanthocyanidin rich cranberry fraction (PAC) to alter gene expression, induce apoptosis and impact the cell cycle machinery of human NCI-H460 lung cancer cells. Lung cancer is the leading cause of cancer-related deaths in the United States and five year survival rates remain poor at 16%. Thus, assessing potential inhibitors of lung cancer-linked signaling pathways is an active area of investigation.
Keywords: cranberry; tannins; proanthocyanidins; flavan-3-ols; apoptosis; cancer cells; global gene expression; cell cycle

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MDPI and ACS Style

Kresty, L.A.; Howell, A.B.; Baird, M. Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis. Molecules 2011, 16, 2375-2390.

AMA Style

Kresty LA, Howell AB, Baird M. Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis. Molecules. 2011; 16(3):2375-2390.

Chicago/Turabian Style

Kresty, Laura A.; Howell, Amy B.; Baird, Maureen. 2011. "Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis." Molecules 16, no. 3: 2375-2390.

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