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Molecules 2011, 16(3), 2107-2118; doi:10.3390/molecules16032107

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)

1,* , 2
1 Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico 2 Ezose Sciences Inc, Pine Brook, New Jersey 07058, USA 3 Parasitología Experimental, Instituto Nacional de Pediatría, Mexico, D.F. Mexico 4 Laboratorio de Virus y Cáncer, Unidad de Investigación Biomédica en Cáncer. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Cancerología, Secretaría de Salud, Mexico, D.F., Mexico 5 Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), México, D.F., Mexico 6 Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico 7 Escuela Superior de Cómputo, Instituto Politécnico Nacional, México, D.F., Mexico
* Author to whom correspondence should be addressed.
Received: 16 December 2010 / Revised: 25 February 2011 / Accepted: 28 February 2011 / Published: 2 March 2011
(This article belongs to the Section Organic Synthesis)
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Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent  effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.
Keywords: lectins; tepary beans; cytotoxicity; tepary bean lectins lectins; tepary beans; cytotoxicity; tepary bean lectins
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Valadez-Vega, C.; Alvarez-Manilla, G.; Riverón-Negrete, L.; García-Carrancá, A.; Morales-González, J.A.; Zuñiga-Pérez, C.; Madrigal-Santillán, E.; Esquivel-Soto, J.; Esquivel-Chirino, C.; Villagómez-Ibarra, R.; Bautista, M.; Morales-González, Á. Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A). Molecules 2011, 16, 2107-2118.

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