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Molecules 2011, 16(3), 2107-2118; doi:10.3390/molecules16032107
Article

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)

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Received: 16 December 2010; in revised form: 25 February 2011 / Accepted: 28 February 2011 / Published: 2 March 2011
(This article belongs to the Section Organic Synthesis)
Download PDF [238 KB, uploaded 18 June 2014]
Abstract: Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent  effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.
Keywords: lectins; tepary beans; cytotoxicity; tepary bean lectins lectins; tepary beans; cytotoxicity; tepary bean lectins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Valadez-Vega, C.; Alvarez-Manilla, G.; Riverón-Negrete, L.; García-Carrancá, A.; Morales-González, J.A.; Zuñiga-Pérez, C.; Madrigal-Santillán, E.; Esquivel-Soto, J.; Esquivel-Chirino, C.; Villagómez-Ibarra, R.; Bautista, M.; Morales-González, Á. Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A). Molecules 2011, 16, 2107-2118.

AMA Style

Valadez-Vega C, Alvarez-Manilla G, Riverón-Negrete L, García-Carrancá A, Morales-González JA, Zuñiga-Pérez C, Madrigal-Santillán E, Esquivel-Soto J, Esquivel-Chirino C, Villagómez-Ibarra R, Bautista M, Morales-González Á. Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A). Molecules. 2011; 16(3):2107-2118.

Chicago/Turabian Style

Valadez-Vega, Carmen; Alvarez-Manilla, Gerardo; Riverón-Negrete, Leticia; García-Carrancá, Alejandro; Morales-González, José A.; Zuñiga-Pérez, Clara; Madrigal-Santillán, Eduardo; Esquivel-Soto, Jaime; Esquivel-Chirino, Cesar; Villagómez-Ibarra, Roberto; Bautista, Mirandeli; Morales-González, Ángel. 2011. "Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)." Molecules 16, no. 3: 2107-2118.


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