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Anti-Inflammatory and Antioxidant Components from Hygroryza aristata
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 4 January 2011; in revised form: 21 February 2011 / Accepted: 23 February 2011 / Published: 25 February 2011
Abstract: Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7’R*,8’S*)-icariol A2-9-O-b-xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 ± 0.86 and 24.14 ± 1.59 mM, respectively.
Keywords: Hygroryza aristata; Gramineae; hygarine; anti-inflammatory; antioxidant
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Chung, Y.-M.; Lan, Y.-H.; Hwang, T.-L.; Leu, Y.-L. Anti-Inflammatory and Antioxidant Components from Hygroryza aristata. Molecules 2011, 16, 1917-1927.
Chung Y-M, Lan Y-H, Hwang T-L, Leu Y-L. Anti-Inflammatory and Antioxidant Components from Hygroryza aristata. Molecules. 2011; 16(3):1917-1927.
Chung, Yu-Ming; Lan, Yu-Hsuan; Hwang, Tsong-Long; Leu, Yann-Lii. 2011. "Anti-Inflammatory and Antioxidant Components from Hygroryza aristata." Molecules 16, no. 3: 1917-1927.