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Molecules 2011, 16(3), 1917-1927; doi:10.3390/molecules16031917

Anti-Inflammatory and Antioxidant Components from Hygroryza aristata

1
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 January 2011 / Revised: 21 February 2011 / Accepted: 23 February 2011 / Published: 25 February 2011
(This article belongs to the Section Natural Products)
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Abstract

Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7’R*,8’S*)-icariol A2-9-O-b-xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 ± 0.86 and 24.14 ± 1.59 mM, respectively.
Keywords: Hygroryza aristata; Gramineae; hygarine; anti-inflammatory; antioxidant Hygroryza aristata; Gramineae; hygarine; anti-inflammatory; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chung, Y.-M.; Lan, Y.-H.; Hwang, T.-L.; Leu, Y.-L. Anti-Inflammatory and Antioxidant Components from Hygroryza aristata. Molecules 2011, 16, 1917-1927.

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