Next Article in Journal
Comparison of A and B Starch Granules from Three Wheat Varieties
Previous Article in Journal
Biotransformation of (1S)-2-Carene and (1S)-3-Carene by Picea abies Suspension Culture
Molecules 2011, 16(12), 10556-10569; doi:10.3390/molecules161210556
Article

The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model

1,2, 1, 1, 1, 1, 1, 1,*  and 1,*
1 Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Xinqiao Street No. 2, Chongqing 400037, China 2 Department of Oncology, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China
* Authors to whom correspondence should be addressed.
Received: 31 October 2011 / Revised: 25 November 2011 / Accepted: 5 December 2011 / Published: 19 December 2011
Download PDF [433 KB, uploaded 18 June 2014]   |  

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Clinical and laboratory studies have suggested that multi-targeting approaches against neoplastic cells could help to increase patient survival and might reduce the emergence of cells that are resistant to single-target inhibitors. Artesunate (ART) is one of the most potent and rapidly acting antimalarial agents known, and it also exerts a profound cytotoxic activity toward cancer cells and reverses multi-drug resistance. In the present study, we found that artesunate inhibited NSCLC A549 cell growth and proliferation, induced apoptosis and suppressed tumor growth in a dose-dependent manner in A549 cells and a mouse xenograft model. Furthermore, artesunate down-regulated the expression of epidermal growth factor receptor (EGFR), Akt and ATP-binding cassette subfamily G member 2 (ABCG2) at the mRNA and protein levels in vitro and in vivo. In conclusion, artesunate is an effective anti-cancer drug that may enhance the effectiveness of other anticancer drugs and may reverse multi-drug resistance by suppressing the transcription of ABCG2, which inhibits drug efflux.
Keywords: EGFR; ABCG2; Akt; artesunate; NSCLC; multi-drug resistance EGFR; ABCG2; Akt; artesunate; NSCLC; multi-drug resistance
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Ma, H.; Yao, Q.; Zhang, A.-M.; Lin, S.; Wang, X.-X.; Wu, L.; Sun, J.-G.; Chen, Z.-T. The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model. Molecules 2011, 16, 10556-10569.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert