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Molecules 2011, 16(1), 970-1010; doi:10.3390/molecules16010970

Recent Advances in the Application of Chiral Phosphine Ligands in Pd-Catalysed Asymmetric Allylic Alkylation

Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, 04510 México D.F., Mexico
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Received: 20 December 2010 / Revised: 18 January 2011 / Accepted: 19 January 2011 / Published: 21 January 2011
(This article belongs to the Special Issue Homogeneous Catalysis)
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Abstract

One of the most powerful approaches for the formation of simple and complex chiral molecules is the metal-catalysed asymmetric allylic alkylation. This reaction has been broadly studied with a great variety of substrates and nucleophiles under different reaction conditions and it has promoted the synthesis of new chiral ligands to be evaluated as asymmetric inductors. Although the mechanism as well as the active species equilibria are known, the performance of the catalytic system depends on the fine tuning of factors such as type of substrate, nucleophile nature, reaction medium, catalytic precursor and type of ligand used. Particularly interesting are chiral phosphines which have proved to be effective asymmetric inductors in several such reactions. The present review covers the application of phosphine-donor ligands in Pd-catalysed asymmetric allylic alkylation in the last decade.
Keywords: allylic alkylation; asymmetric catalysis; chiral phosphines; palladium allylic alkylation; asymmetric catalysis; chiral phosphines; palladium
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MDPI and ACS Style

Guerrero Rios, I.; Rosas-Hernandez, A.; Martin, E. Recent Advances in the Application of Chiral Phosphine Ligands in Pd-Catalysed Asymmetric Allylic Alkylation. Molecules 2011, 16, 970-1010.

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