Molecules 2011, 16(1), 107-118; doi:10.3390/molecules16010107

Antimalarial Activity of Methanolic Leaf Extract of Piper betle L.

1,* email, 1email, 1email, 2email and 1email
Received: 25 November 2010; in revised form: 18 December 2010 / Accepted: 21 December 2010 / Published: 28 December 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50–400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis.
Keywords: Piper betle; methanolic extract; antimalarial activity
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MDPI and ACS Style

Al-Adhroey, A.H.; Nor, Z.M.; Al-Mekhlafi, H.M.; Amran, A.A.; Mahmud, R. Antimalarial Activity of Methanolic Leaf Extract of Piper betle L.. Molecules 2011, 16, 107-118.

AMA Style

Al-Adhroey AH, Nor ZM, Al-Mekhlafi HM, Amran AA, Mahmud R. Antimalarial Activity of Methanolic Leaf Extract of Piper betle L.. Molecules. 2011; 16(1):107-118.

Chicago/Turabian Style

Al-Adhroey, Abdulelah H.; Nor, Zurainee M.; Al-Mekhlafi, Hesham M.; Amran, Adel A.; Mahmud, Rohela. 2011. "Antimalarial Activity of Methanolic Leaf Extract of Piper betle L.." Molecules 16, no. 1: 107-118.

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