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Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
Department of Anesthesiology, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan
Graduate Institute of Integrated Medicine, College of Chinese Medicine, Graduate Institute of Clinical Medical Science, Department of Urology, Department of Neurosurgery, China Medical University and Hospital, Taichung, Taiwan
Graduate Institute of Geriatric Medicine, Anhui Medical University, Hefei, China
Division of Cardiology, Taipei Veterans General Hospital, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan
Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Jui-Lung Shen and Kee-Ming Man contributed equally to this study.
* Authors to whom correspondence should be addressed.
Received: 27 August 2010; in revised form: 7 September 2010 / Accepted: 15 September 2010 / Published: 16 September 2010
Abstract: Chinese herbs have been and still are widely used as important remedies in Oriental medicine. Over the recent years, a variety of biologically active constituents have been isolated from these sources and confirmed to have multifunctional activity in experimental studies. Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares certain biological properties. Recently, honokiol and magnolol have been found to have anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties in preclinical models, without appreciable toxicity. These findings have increased interest in bringing honokiol and magnolol to the clinic as novel therapeutic agents in dermatology. In this review, the findings concerning the major mechanisms of action of honokiol and magnolol are described. Knowledge of the multiple activities of honokiol and magnolol can assist with the development of honokiol and magnolol derivatives and the design of clinical trials that will maximize the potential benefit of honokiol and magnolol in the patient setting for dermatologic disorders.
Keywords: antibacterial; antioxidant; Chinese medicine; dermatology; honokiol; inflammation; magnolol
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Shen, J.-L.; Man, K.-M.; Huang, P.-H.; Chen, W.-C.; Chen, D.-C.; Cheng, Y.-W.; Liu, P.-L.; Chou, M.-C.; Chen, Y.-H. Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders. Molecules 2010, 15, 6452-6465.
Shen J-L, Man K-M, Huang P-H, Chen W-C, Chen D-C, Cheng Y-W, Liu P-L, Chou M-C, Chen Y-H. Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders. Molecules. 2010; 15(9):6452-6465.
Shen, Jui-Lung; Man, Kee-Ming; Huang, Po-Hsun; Chen, Wen-Chi; Chen, Der-Cherng; Cheng, Ya-Wen; Liu, Po-Len; Chou, Ming-Chih; Chen, Yung-Hsiang. 2010. "Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders." Molecules 15, no. 9: 6452-6465.