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Molecules 2010, 15(9), 5840-5849; doi:10.3390/molecules15095840
Article

Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats

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Received: 23 June 2010; in revised form: 18 August 2010 / Accepted: 20 August 2010 / Published: 26 August 2010
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Abstract: The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N-(4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.
Keywords: Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides; high-density lipoprotein-cholesterol; triglycerides; hypolipidemic activity Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides; high-density lipoprotein-cholesterol; triglycerides; hypolipidemic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shattat, G.; Al-Qirim, R.; Al-Hiari, Y.; Sheikha, G.A.; Al-Qirim, T.; El-Huneidi, W.; Shahwan, M. Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules 2010, 15, 5840-5849.

AMA Style

Shattat G, Al-Qirim R, Al-Hiari Y, Sheikha GA, Al-Qirim T, El-Huneidi W, Shahwan M. Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules. 2010; 15(9):5840-5849.

Chicago/Turabian Style

Shattat, Ghassan; Al-Qirim, Rania; Al-Hiari, Yusuf; Sheikha, Ghassan Abu; Al-Qirim, Tariq; El-Huneidi, Waseem; Shahwan, Moyad. 2010. "Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats." Molecules 15, no. 9: 5840-5849.


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