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Molecules 2010, 15(9), 5840-5849; doi:10.3390/molecules15095840

Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats

1
Faculty of Pharmacy, Al-Zaytoonah Private University, Amman, Jordan
2
Faculty of Pharmacy, University of Jordan, Amman, Jordan
*
Author to whom correspondence should be addressed.
Received: 23 June 2010 / Revised: 18 August 2010 / Accepted: 20 August 2010 / Published: 26 August 2010
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Abstract

The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N-(4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.
Keywords: Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides; high-density lipoprotein-cholesterol; triglycerides; hypolipidemic activity Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides; high-density lipoprotein-cholesterol; triglycerides; hypolipidemic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shattat, G.; Al-Qirim, R.; Al-Hiari, Y.; Sheikha, G.A.; Al-Qirim, T.; El-Huneidi, W.; Shahwan, M. Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules 2010, 15, 5840-5849.

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