Molecules 2010, 15(8), 5093-5103; doi:10.3390/molecules15085093
Article

Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity

Received: 12 May 2010; in revised form: 13 July 2010 / Accepted: 26 July 2010 / Published: 27 July 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Prunella vulgaris L. (PV) has been used for tumor therapy in Traditional Chinese Medicine for centuries, however, systematic research on extracted PV polysaccharides believed to possess various biological activities, as well as their preventive and anti-tumor effects on lung cancer has not been reported. In this study, two polysaccharides (P31 and P32) were isolated from the aqueous extract of PV and purified through ethanol precipitation, followed by deproteination using DEAE-52 gel-filtration chromatography. The main monosaccharide composition of polysaccharide P32 was analyzed by GC. It was found that polysaccharide P32 consisted of rhamnose, arabinose, xylose, mannose, glucose and galactose in a molar ratio of 3.46:49.32:58.91:0.43:2.64: 3.11, respectively. In order to evaluate polysaccharide P32’s anti-lung adenocarcinoma activities and immunomodulation effects, a C57BL/6 mouse-Lewis lung carcinoma (LLC) model was established and investigated. Our results showed that polysaccharides of PV had anti-lung cancer activity and could increase the thymus index and the spleen index in tumor-bearing mice, suggesting possible immunomodulation effects.
Keywords: Prunella vulgaris L.; polysaccharide; GC; anti-lung adenocarcinoma; immune function
PDF Full-text Download PDF Full-Text [161 KB, uploaded 18 June 2014 19:33 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Feng, L.; Jia, X.-B.; Shi, F.; Chen, Y. Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity. Molecules 2010, 15, 5093-5103.

AMA Style

Feng L, Jia X-B, Shi F, Chen Y. Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity. Molecules. 2010; 15(8):5093-5103.

Chicago/Turabian Style

Feng, Liang; Jia, Xiao-Bin; Shi, Feng; Chen, Yan. 2010. "Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity." Molecules 15, no. 8: 5093-5103.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert