Molecules 2010, 15(4), 2398-2404; doi:10.3390/molecules15042398
Article

Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum

Gwendoline Cheng Lian Ee 1,* email, Chyi Meei Lim 1 , Mawardi Rahmani 1 , Khozirah Shaari 1  and Choon Fah Joseph Bong 2
1 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia 2 Department of Crop Science, Faculty of Agriculture & Food Sciences, Universiti Putra Malaysia Bintulu Campus, 97008, Bintulu, Sarawak, Malaysia
* Author to whom correspondence should be addressed.
Received: 12 January 2010; in revised form: 9 March 2010 / Accepted: 18 March 2010 / Published: 5 April 2010
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Abstract: Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
Keywords: Piper nigrum; pellitorine; alkaloids; cytotoxicity; microbial transformation; aspergillus niger

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MDPI and ACS Style

Ee, G.C.L.; Lim, C.M.; Rahmani, M.; Shaari, K.; Bong, C.F.J. Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum. Molecules 2010, 15, 2398-2404.

AMA Style

Ee GCL, Lim CM, Rahmani M, Shaari K, Bong CFJ. Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum. Molecules. 2010; 15(4):2398-2404.

Chicago/Turabian Style

Ee, Gwendoline Cheng Lian; Lim, Chyi Meei; Rahmani, Mawardi; Shaari, Khozirah; Bong, Choon Fah Joseph. 2010. "Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum." Molecules 15, no. 4: 2398-2404.

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