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Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
Department of Anatomic Pathology, Hospital A.C Camargo, São Paulo, Rua Antonio Prudente, 109–1 andar, CEP: 01509-010, São Paulo, SP, Brazil
Department of Head and Neck, Hospital A.C Camargo, São Paulo, SP, Brazil
Department of Head and Neck, Hospital do Cancer, Barretos, SP, Brazil
Department of General Pathology, Dental School, University of São Paulo, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 25 February 2010; in revised form: 24 March 2010 / Accepted: 29 March 2010 / Published: 1 April 2010
Abstract: We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value. Methods: Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A.C.Camargo hospital records. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. IHC results were evaluated according to the staining pattern and number of positive cells. Results: GLUT 1 was over expressed in 50.3% of OSSC cases showing membrane staining pattern. However, nuclear expression was observed in 49.7% of the analyzed cases. GLUT 3 over expression was detected in 21.1% of OSCC cases. The pattern of GLUT 1 expression showed significant association with alcohol consumption (p = 0.004). Positive cell membrane GLUT 3 protein expression was associated with advanced clinic-staging of tumours (p = 0.005) as well as with vascular embolization (p = 0.005). Positive expression of GLUT 3 was associated with unfavorable free-disease survival (p = 0.021). Conclusion: GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells.
Keywords: oral carcinoma; GLUT1; GLUT3; immunohistochemistry
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Ayala, F.R.R.; Rocha, R.M.; Carvalho, K.C.; Carvalho, A.L.; Da Cunha, I.W.; Lourenço, S.V.; Soares, F.A. Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma. Molecules 2010, 15, 2374-2387.
Ayala FRR, Rocha RM, Carvalho KC, Carvalho AL, Da Cunha IW, Lourenço SV, Soares FA. Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma. Molecules. 2010; 15(4):2374-2387.
Ayala, Fernanda Rocha Rojas; Rocha, Rafael Malagoli; Carvalho, Kátia Cândido; Carvalho, André Lopes; Da Cunha, Isabela Werneck; Lourenço, Silvia Vanessa; Soares, Fernando Augusto. 2010. "Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma." Molecules 15, no. 4: 2374-2387.