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Molecules 2010, 15(4), 2060-2069; doi:10.3390/molecules15042060

Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA)

1
Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Brazil
2
Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Brazil
3
Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Av. Colombo, 5790, 87020-900, Maringá, Brazil
*
Author to whom correspondence should be addressed.
Received: 18 January 2010 / Revised: 21 March 2010 / Accepted: 23 March 2010 / Published: 24 March 2010
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Abstract

Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck (Piperaceae) is a medicinal plant traditionally used in Brazil to treat infectious diseases. The extracts obtained of the leaves from P. regnellii were investigated for their antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). The ethyl acetate extract presented a good activity against MRSA, with minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 16 μg/mL. Based on this finding, the ethyl acetate extract was fractionated by silica gel column chromatography into nine fractions. The hexane fraction was active against MRSA (MIC at 4 μg/mL). Further column chromatography separation of the hexane fraction afforded the pure compound eupomatenoid-5. The structure of the compound was established by spectral data (1H and 13C NMR HSQC, HMBC, gNOE, IR and MS). Eupomatenoid-5 was the only compound active on the bacterium. The antibacterial property of P. regnellii extract provides preliminary scientific validation for the traditional medicinal use of this plant. The active compound eupomatenoid-5 should be further studied in animal models to verify in vivo efficacy and toxicity.
Keywords: Piper regnellii; Staphylococcus aureus; neolignans; MRSA; antibacterial activity Piper regnellii; Staphylococcus aureus; neolignans; MRSA; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Marçal, F.J.B.; Cortez, D.A.G.; Ueda-Nakamura, T.; Nakamura, C.V.; Filho, B.P.D. Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA). Molecules 2010, 15, 2060-2069.

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