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Molecules 2010, 15(2), 997-1006; doi:10.3390/molecules15020997
Article

Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization

1,* , 1, 2 and 3,*
Received: 26 December 2009; in revised form: 22 February 2010 / Accepted: 22 February 2010 / Published: 23 February 2010
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Abstract: The title compounds, (4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles, were prepared in four steps starting from commercially available 4-trifluoromethoxyaniline. The pyrrole (second ring) was added in one step using the Paal-Knorr method. The thiazole (third ring) was added in three steps using chloroacylation with chloroacetonitrile followed by heterocyclization with thioamides/thioureas.
Keywords: pyrrole; fluorinated heterocycles; Paal-Knorr reaction; trifluoromethoxy group; chain heterocyclization pyrrole; fluorinated heterocycles; Paal-Knorr reaction; trifluoromethoxy group; chain heterocyclization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vovk, M.V.; Pinchuk, O.M.; Tolmachov, A.O.; Gakh, A.A. Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization. Molecules 2010, 15, 997-1006.

AMA Style

Vovk MV, Pinchuk OM, Tolmachov AO, Gakh AA. Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization. Molecules. 2010; 15(2):997-1006.

Chicago/Turabian Style

Vovk, Mykhaylo V.; Pinchuk, Oleksandr M.; Tolmachov, Andrij O.; Gakh, Andrei A. 2010. "Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization." Molecules 15, no. 2: 997-1006.


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