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A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin
Laboratorio de Farmacología Molecular del Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba
Clínica del Dolor Hospital Docente Clínico Quirúrgico 10 de Octubre, Calzada de 10 de Octubre, 130 entre Alejandro Ramírez y Agua Dulce, Havana, Cuba
Departamento de Química y Farmacia, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile
* Author to whom correspondence should be addressed.
Received: 27 October 2010; in revised form: 29 November 2010 / Accepted: 1 December 2010 / Published: 9 December 2010
Abstract: It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic pain. Vimang is an aqueous extract of Mangifera indica L. traditionally used in Cuba for its analgesic, anti-inflammatory, antioxidant and immunomodulatory properties. Several formulations are available, and also for mangiferin, its major component. Preclinical studies demonstrated that these products prevented tumor necrosis factor α -induced IκB degradation and the binding of nuclear factor κB to DNA, which induces the transcription of genes implicated in the expression of some mediators and enzymes involved in inflammation, pain, oxidative stress and synaptic plasticity. In this paper we propose its potential utility in the neuropathic pain treatment. This hypothesis is supported in the cumulus of preclinical and clinical evidence around the extract and mangiferin, its major component, and speculates about the possible mechanism of action according to recent advances in the physiopathology of neuropathic pain.
Keywords: neuropathic pain; neuroimmune mechanisms; Vimang; Mangifera indica L.; mangiferin
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Garrido-Suárez, B.B.; Garrido, G.; Delgado, R.; Bosch, F.; Rabí, M.C. A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin. Molecules 2010, 15, 9035-9045.
Garrido-Suárez BB, Garrido G, Delgado R, Bosch F, Rabí MC. A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin. Molecules. 2010; 15(12):9035-9045.
Garrido-Suárez, Bárbara B.; Garrido, Gabino; Delgado, Rene; Bosch, Fe; Rabí, María del C. 2010. "A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin." Molecules 15, no. 12: 9035-9045.