Next Article in Journal
Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa
Previous Article in Journal
Selective Inhibitory Effect of Epigallocatechin-3-gallate on Migration of Vascular Smooth Muscle Cells
Article Menu

Article Versions

Export Article

Open AccessCommunication
Molecules 2010, 15(11), 8501-8506; doi:10.3390/molecules15118501

Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction

Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China
Author to whom correspondence should be addressed.
Received: 9 October 2010 / Revised: 14 November 2010 / Accepted: 14 November 2010 / Published: 22 November 2010
Download PDF [178 KB, uploaded 18 June 2014]


In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis.
Keywords: phenanthroindolizidine; antitumor; Friedel-Crafts reaction phenanthroindolizidine; antitumor; Friedel-Crafts reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, S.; Han, L.; Liu, J.; Hu, Y.; Zheng, D.; Fu, Y.; Huang, X. Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction. Molecules 2010, 15, 8501-8506.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top