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Molecules 2010, 15(11), 8501-8506; doi:10.3390/molecules15118501
Communication

Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction

, , , , ,  and *
Received: 9 October 2010 / Revised: 14 November 2010 / Accepted: 14 November 2010 / Published: 22 November 2010
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Abstract

In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis.
Keywords: phenanthroindolizidine; antitumor; Friedel-Crafts reaction phenanthroindolizidine; antitumor; Friedel-Crafts reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, S.; Han, L.; Liu, J.; Hu, Y.; Zheng, D.; Fu, Y.; Huang, X. Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction. Molecules 2010, 15, 8501-8506.

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