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Molecules 2010, 15(11), 8501-8506; doi:10.3390/molecules15118501

Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction

, , , , ,  and *
Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China
* Author to whom correspondence should be addressed.
Received: 9 October 2010 / Revised: 14 November 2010 / Accepted: 14 November 2010 / Published: 22 November 2010
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In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis.
Keywords: phenanthroindolizidine; antitumor; Friedel-Crafts reaction phenanthroindolizidine; antitumor; Friedel-Crafts reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, S.; Han, L.; Liu, J.; Hu, Y.; Zheng, D.; Fu, Y.; Huang, X. Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction. Molecules 2010, 15, 8501-8506.

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