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Molecules 2010, 15(11), 8327-8348; doi:10.3390/molecules15118327
Article

Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole

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Received: 20 October 2010; in revised form: 8 November 2010 / Accepted: 10 November 2010 / Published: 15 November 2010
(This article belongs to the Special Issue Bifunctional Catalysis)
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Abstract: The synthesis and properties of multifunctional thioureas bearing a variety of functional groups at a position remote from the thiourea moiety are described. A 1,5-disubstituted triazole tether connected with a thiourea and another functional group was synthesized via ruthenium catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as asymmetric catalysts and probes for the mechanistic elucidation of the course of the Michael reaction of an α,β-unsaturated imide
Keywords: multifunctional catalyst; thiourea; Ru-catalyzed Huisgen cycloaddition; asymmetric induction; hydrogen bonding multifunctional catalyst; thiourea; Ru-catalyzed Huisgen cycloaddition; asymmetric induction; hydrogen bonding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Takasu, K.; Azuma, T.; Enkhtaivan, I.; Takemoto, Y. Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole. Molecules 2010, 15, 8327-8348.

AMA Style

Takasu K, Azuma T, Enkhtaivan I, Takemoto Y. Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole. Molecules. 2010; 15(11):8327-8348.

Chicago/Turabian Style

Takasu, Kiyosei; Azuma, Takumi; Enkhtaivan, Iderbat; Takemoto, Yoshiji. 2010. "Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole." Molecules 15, no. 11: 8327-8348.


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