Molecules 2010, 15(11), 8082-8097; doi:10.3390/molecules15118082
Article

Synthesis of Non-Cytotoxic Poly(Ester-Amine) Dendrimers as Potential Solubility Enhancers for Drugs: Methotrexate as a Case Study

Delia Soto-Castro 1 email, Jorge A. Cruz-Morales 1 email, María Teresa Ramírez Apan 2 email and Patricia Guadarrama 1,* email
1 Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apartado Postal 70-360, CU, Coyoacán, Mexico, DF, 04510, Mexico 2 Instituto de Química, Universidad Nacional Autónoma de México, Apartado Postal 70-213, CU, Coyoacán, Mexico, DF, 04510, Mexico
* Author to whom correspondence should be addressed.
Received: 8 October 2010; in revised form: 20 October 2010 / Accepted: 4 November 2010 / Published: 9 November 2010
(This article belongs to the Section Organic Synthesis)
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Abstract: This study describes the synthesis of two new families of dendrimers based on the esterification of N-alkylated 3-amine-1-propanol with two different cores, adipic acid (1st and 2nd generations) and ethylenediamine (generation 1.5), both with carboxylic acid end groups, offering a wide variety of further modifications at the periphery. According to the cytotoxic evaluation of the dendrimers and their possible degradation products within cell lines, these materials could be considered as innocuous. In preliminary studies, the synthesized dendrimers proved to be potential enhancers of solubility of highly hydrophobic drugs, like methotrexate, widely used in chemotherapy.
Keywords: non-cytotoxic dendrimers; solubility enhancer; methotrexate

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MDPI and ACS Style

Soto-Castro, D.; Cruz-Morales, J.A.; Apan, M.T.R.; Guadarrama, P. Synthesis of Non-Cytotoxic Poly(Ester-Amine) Dendrimers as Potential Solubility Enhancers for Drugs: Methotrexate as a Case Study. Molecules 2010, 15, 8082-8097.

AMA Style

Soto-Castro D, Cruz-Morales JA, Apan MTR, Guadarrama P. Synthesis of Non-Cytotoxic Poly(Ester-Amine) Dendrimers as Potential Solubility Enhancers for Drugs: Methotrexate as a Case Study. Molecules. 2010; 15(11):8082-8097.

Chicago/Turabian Style

Soto-Castro, Delia; Cruz-Morales, Jorge A.; Apan, María Teresa Ramírez; Guadarrama, Patricia. 2010. "Synthesis of Non-Cytotoxic Poly(Ester-Amine) Dendrimers as Potential Solubility Enhancers for Drugs: Methotrexate as a Case Study." Molecules 15, no. 11: 8082-8097.

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