Next Article in Journal
Preparation of a Carbon-Based Solid Acid Catalyst by Sulfonating Activated Carbon in a Chemical Reduction Process
Next Article in Special Issue
The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants
Previous Article in Journal
Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats
Previous Article in Special Issue
Effects of Different Maturity Stages on Antioxidant Content of Ivorian Gnagnan (Solanum indicum L.) Berries
Article Menu

Article Versions

Export Article

Open AccessReview
Molecules 2010, 15(10), 7167-7187; doi:10.3390/molecules15107167

Role of Oxidant Scavengers in the Prevention of Ca2+ Homeostasis Disorders

Cell Physiology Research Group, Department of Physiology, University of Extremadura, Caceres, 10071, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 1 July 2010 / Revised: 9 September 2010 / Accepted: 14 October 2010 / Published: 15 October 2010
(This article belongs to the Special Issue Antioxidants)
Download PDF [173 KB, uploaded 18 June 2014]   |  

Abstract

A number of disorders, such as Alzheimer disease and diabetes mellitus, have in common the alteration of the redox balance, resulting in an increase in reactive oxygen species (ROS) generation that might lead to the development of apoptosis and cell death. It has long been known that ROS can significantly alter Ca2+ mobilization, an intracellular signal that is involved in the regulation of a wide variety of cellular functions. Cells have a limited capability to counteract the effects of oxidative stress, but evidence has been provided supporting the beneficial effects of exogenous ROS scavengers. Here, we review the effects of oxidative stress on intracellular Ca2+ homeostasis and the role of antioxidants in the prevention and treatment of disorders associated to abnormal Ca2+ mobilization induced by ROS.
Keywords: reactive oxygen species; scavengers; antioxidants; intracellular Ca2+ homeostasis reactive oxygen species; scavengers; antioxidants; intracellular Ca2+ homeostasis
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Galan, C.; Jardín, I.; Dionisio, N.; Salido, G.; Rosado, J.A. Role of Oxidant Scavengers in the Prevention of Ca2+ Homeostasis Disorders. Molecules 2010, 15, 7167-7187.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top