Role of Oxidant Scavengers in the Prevention of Ca2+ Homeostasis Disorders

doi:10.3390/molecules15107167

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Molecules 2010, 15(10), 7167-7187; doi:10.3390/molecules15107167

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Role of Oxidant Scavengers in the Prevention of Ca²⁺ Homeostasis Disorders

Carmen Galan^†, Isaac Jardín^†, Natalia Dionisio^†, Ginés Salido and Juan A. Rosado*

Cell Physiology Research Group, Department of Physiology, University of Extremadura, Caceres, 10071, Spain ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 1 July 2010; in revised form: 9 September 2010 / Accepted: 14 October 2010 / Published: 15 October 2010

(This article belongs to the Special Issue Antioxidants)

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Abstract: A number of disorders, such as Alzheimer disease and diabetes mellitus, have in common the alteration of the redox balance, resulting in an increase in reactive oxygen species (ROS) generation that might lead to the development of apoptosis and cell death. It has long been known that ROS can significantly alter Ca²⁺ mobilization, an intracellular signal that is involved in the regulation of a wide variety of cellular functions. Cells have a limited capability to counteract the effects of oxidative stress, but evidence has been provided supporting the beneficial effects of exogenous ROS scavengers. Here, we review the effects of oxidative stress on intracellular Ca²⁺ homeostasis and the role of antioxidants in the prevention and treatment of disorders associated to abnormal Ca²⁺ mobilization induced by ROS.

Keywords: reactive oxygen species; scavengers; antioxidants; intracellular Ca²⁺ homeostasis

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MDPI and ACS Style

Galan, C.; Jardín, I.; Dionisio, N.; Salido, G.; Rosado, J.A. Role of Oxidant Scavengers in the Prevention of Ca²⁺ Homeostasis Disorders. Molecules 2010, 15, 7167-7187.

AMA Style

Galan C, Jardín I, Dionisio N, Salido G, Rosado JA. Role of Oxidant Scavengers in the Prevention of Ca²⁺ Homeostasis Disorders. Molecules. 2010; 15(10):7167-7187.

Chicago/Turabian Style

Galan, Carmen; Jardín, Isaac; Dionisio, Natalia; Salido, Ginés; Rosado, Juan A. 2010. "Role of Oxidant Scavengers in the Prevention of Ca²⁺ Homeostasis Disorders." Molecules 15, no. 10: 7167-7187.

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