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Targeted Thiazole Orange Derivative with Folate: Synthesis, Fluorescence and in Vivo Fluorescence Imaging
School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China
Department of Material Science and Engineering, Tianjin Institute of Urban Construction, Tianjin, 300384, China
* Author to whom correspondence should be addressed.
Received: 19 August 2010; in revised form: 15 September 2010 / Accepted: 25 September 2010 / Published: 11 October 2010
Abstract: A Thiazole Orange conjugated with folate derivative was synthesized in two steps. Firstly, folate was coupled with 1-(3-aminopropyl)-4-methylquinolinium bromide to afford folate-methylquinolinium bromide, which then reacted with benzothiazolium to obtain the title folate-conjugated compound. The compound was evaluated by 1H-NMR MS, TG/DTA and fluorescence spectroscopic methods. The title compound could selectively target folate receptor expressing tumors according to the in vivo fluorescence imaging preliminarily performed on nude mice with breast tumors.
Keywords: thiazole orange; folate; synthesis; targeted label in vivo; fluorescence imaging
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MDPI and ACS Style
Fei, X.; Gu, Y.; Wang, Y.; Meng, Q.; Zhang, B. Targeted Thiazole Orange Derivative with Folate: Synthesis, Fluorescence and in Vivo Fluorescence Imaging. Molecules 2010, 15, 6983-6992.
Fei X, Gu Y, Wang Y, Meng Q, Zhang B. Targeted Thiazole Orange Derivative with Folate: Synthesis, Fluorescence and in Vivo Fluorescence Imaging. Molecules. 2010; 15(10):6983-6992.
Fei, Xuening; Gu, Yingchun; Wang, Yiqi; Meng, Qingyang; Zhang, Baolian. 2010. "Targeted Thiazole Orange Derivative with Folate: Synthesis, Fluorescence and in Vivo Fluorescence Imaging." Molecules 15, no. 10: 6983-6992.