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Stem Cells for the Treatment of Neurodegenerative Diseases
Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou, 310009, China
* Author to whom correspondence should be addressed.
Received: 13 August 2010; in revised form: 6 September 2010 / Accepted: 8 September 2010 / Published: 27 September 2010
Abstract: Neurodegenerative diseases are characterized by neurodegenerative changes or apoptosis of neurons involved in networks, leading to permanent paralysis and loss of sensation below the site of the injury. Cell replacement therapy has provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. In recent years, neurons and glial cells have successfully been generated from stem cells, and extensive efforts by investigators to develop stem cell-based brain transplantation therapies have been carried out. We review here notable previously published experimental and preclinical studies involving stem cell-based cell for neurodegenerative diseases and discuss the future prospects for stem cell therapy of neurological disorders in the clinical setting. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases.
Keywords: stem cell; neurodegenerative diseases; treatment
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MDPI and ACS Style
Wu, Y.-P.; Chen, W.-S.; Teng, C.; Zhang, N. Stem Cells for the Treatment of Neurodegenerative Diseases. Molecules 2010, 15, 6743-6758.
Wu Y-P, Chen W-S, Teng C, Zhang N. Stem Cells for the Treatment of Neurodegenerative Diseases. Molecules. 2010; 15(10):6743-6758.
Wu, Yong-Ping; Chen, Wei-Shan; Teng, Chong; Zhang, Ning. 2010. "Stem Cells for the Treatment of Neurodegenerative Diseases." Molecules 15, no. 10: 6743-6758.