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Molecules 2009, 14(9), 3694-3699; doi:10.3390/molecules14093694

A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

1 Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China 2 Key Laboratory of Tropic Biological Resources of Ministry of Education, Hainan University, Haikou 570228, China
* Author to whom correspondence should be addressed.
Received: 22 July 2009 / Revised: 8 September 2009 / Accepted: 15 September 2009 / Published: 21 September 2009
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A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
Keywords: Antiaris toxicaria; toxicarioside H; nor-cardenolide; cytotoxicity Antiaris toxicaria; toxicarioside H; nor-cardenolide; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dai, H.-F.; Gan, Y.-J.; Que, D.-M.; Wu, J.; Wen, Z.-C.; Mei, W.-L. A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria. Molecules 2009, 14, 3694-3699.

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