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Molecules 2009, 14(9), 3694-3699; doi:10.3390/molecules14093694

A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

1 Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China 2 Key Laboratory of Tropic Biological Resources of Ministry of Education, Hainan University, Haikou 570228, China
* Author to whom correspondence should be addressed.
Received: 22 July 2009 / Revised: 8 September 2009 / Accepted: 15 September 2009 / Published: 21 September 2009
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A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
Keywords: Antiaris toxicaria; toxicarioside H; nor-cardenolide; cytotoxicity Antiaris toxicaria; toxicarioside H; nor-cardenolide; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dai, H.-F.; Gan, Y.-J.; Que, D.-M.; Wu, J.; Wen, Z.-C.; Mei, W.-L. A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria. Molecules 2009, 14, 3694-3699.

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