Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives

doi:10.3390/molecules14093494

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Molecules 2009, 14(9), 3494-3508; doi:10.3390/molecules14093494

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Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives

Amedeo Pau^1,* , Gabriele Murineddu¹, Battistina Asproni¹, Caterina Murruzzu¹, Giuseppe E. Grella¹, Gérard A. Pinna¹, Maria M. Curzu¹, Irene Marchesi² and Luigi Bagella²

¹ Dipartimento Farmaco Chimico Tossicologico,Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy ² Department of Biomedical Sciences, Division of Biochemistry and Biophysics, and National Institute of Biostructures and Biosystems, University of Sassari, Viale San Pietro 43/b 07100 Sassari, Italy

* Author to whom correspondence should be addressed.

Received: 17 July 2009; in revised form: 26 August 2009 / Accepted: 9 September 2009 / Published: 9 September 2009

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Abstract: Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.

Keywords: pyridazinones; synthesis; cytotoxicity

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MDPI and ACS Style

Pau, A.; Murineddu, G.; Asproni, B.; Murruzzu, C.; Grella, G.E.; Pinna, G.A.; Curzu, M.M.; Marchesi, I.; Bagella, L. Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives. Molecules 2009, 14, 3494-3508.

AMA Style

Pau A., Murineddu G., Asproni B., Murruzzu C., Grella G.E., Pinna G.A., Curzu M.M., Marchesi I., Bagella L. Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives. Molecules. 2009; 14(9):3494-3508.

Chicago/Turabian Style

Pau, Amedeo; Murineddu, Gabriele; Asproni, Battistina; Murruzzu, Caterina; Grella, Giuseppe E.; Pinna, Gérard A.; Curzu, Maria M.; Marchesi, Irene; Bagella, Luigi. 2009. "Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives." Molecules 14, no. 9: 3494-3508.

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