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Molecules 2009, 14(9), 3494-3508; doi:10.3390/molecules14093494

Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives

1,* , 1, 1, 1, 1, 1, 1, 2 and 2
1 Dipartimento Farmaco Chimico Tossicologico,Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy 2 Department of Biomedical Sciences, Division of Biochemistry and Biophysics, and National Institute of Biostructures and Biosystems, University of Sassari, Viale San Pietro 43/b 07100 Sassari, Italy
* Author to whom correspondence should be addressed.
Received: 17 July 2009 / Revised: 26 August 2009 / Accepted: 9 September 2009 / Published: 9 September 2009
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Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
Keywords: pyridazinones; synthesis; cytotoxicity pyridazinones; synthesis; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pau, A.; Murineddu, G.; Asproni, B.; Murruzzu, C.; Grella, G.E.; Pinna, G.A.; Curzu, M.M.; Marchesi, I.; Bagella, L. Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives. Molecules 2009, 14, 3494-3508.

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