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Molecules 2009, 14(9), 3494-3508; doi:10.3390/molecules14093494

Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives

Dipartimento Farmaco Chimico Tossicologico,Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy
Department of Biomedical Sciences, Division of Biochemistry and Biophysics, and National Institute of Biostructures and Biosystems, University of Sassari, Viale San Pietro 43/b 07100 Sassari, Italy
Author to whom correspondence should be addressed.
Received: 17 July 2009 / Revised: 26 August 2009 / Accepted: 9 September 2009 / Published: 9 September 2009
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Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
Keywords: pyridazinones; synthesis; cytotoxicity pyridazinones; synthesis; cytotoxicity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pau, A.; Murineddu, G.; Asproni, B.; Murruzzu, C.; Grella, G.E.; Pinna, G.A.; Curzu, M.M.; Marchesi, I.; Bagella, L. Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives. Molecules 2009, 14, 3494-3508.

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