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Molecules 2009, 14(9), 3353-3359; doi:10.3390/molecules14093353
Article

Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): Efficient Catalysts for the Cyanosilylation and Cyanocarbonation of Aldehydes and Ketones

* ,  and
Department of Science Education, Faculty of Education, Ibaraki University, Ibaraki, 310-8512 Japan
* Author to whom correspondence should be addressed.
Received: 6 August 2009 / Revised: 25 August 2009 / Accepted: 31 August 2009 / Published: 2 September 2009
(This article belongs to the Special Issue Organocatalysis)
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Abstract

A variety of aldehydes and ketones were transformed to their corresponding cyanohydrin silyl ethers in good to excellent yields in the presence of 1-5 mol% of tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP). Cyanohydrin carbonates were also readily prepared using 5-10 mol% of TTMPP as an organocatalyst.
Keywords: organocatalysis; cyanosilylaton; cyanohydrin carbonate; phosphines; cyanation organocatalysis; cyanosilylaton; cyanohydrin carbonate; phosphines; cyanation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Matsukawa, S.; Sekine, I.; Iitsuka, A. Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): Efficient Catalysts for the Cyanosilylation and Cyanocarbonation of Aldehydes and Ketones. Molecules 2009, 14, 3353-3359.

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