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Molecules 2009, 14(9), 3353-3359; doi:10.3390/molecules14093353
Article

Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): Efficient Catalysts for the Cyanosilylation and Cyanocarbonation of Aldehydes and Ketones

* ,  and
Department of Science Education, Faculty of Education, Ibaraki University, Ibaraki, 310-8512 Japan
* Author to whom correspondence should be addressed.
Received: 6 August 2009 / Revised: 25 August 2009 / Accepted: 31 August 2009 / Published: 2 September 2009
(This article belongs to the Special Issue Organocatalysis)
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Abstract

A variety of aldehydes and ketones were transformed to their corresponding cyanohydrin silyl ethers in good to excellent yields in the presence of 1-5 mol% of tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP). Cyanohydrin carbonates were also readily prepared using 5-10 mol% of TTMPP as an organocatalyst.
Keywords: organocatalysis; cyanosilylaton; cyanohydrin carbonate; phosphines; cyanation organocatalysis; cyanosilylaton; cyanohydrin carbonate; phosphines; cyanation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Matsukawa, S.; Sekine, I.; Iitsuka, A. Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): Efficient Catalysts for the Cyanosilylation and Cyanocarbonation of Aldehydes and Ketones. Molecules 2009, 14, 3353-3359.

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