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Molecules 2009, 14(9), 3286-3312; doi:10.3390/molecules14093286

Squalene Emulsions for Parenteral Vaccine and Drug Delivery

Infectious Disease Research Institute, 1124 Columbia St, Ste 400, Seattle, WA 98104, USA
Received: 13 August 2009 / Revised: 25 August 2009 / Accepted: 31 August 2009 / Published: 1 September 2009
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytica techniques for characterization of squalene emulsions are examined.
Keywords: squalene; squalane; adjuvant; emulsion; parenteral squalene; squalane; adjuvant; emulsion; parenteral
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fox, C.B. Squalene Emulsions for Parenteral Vaccine and Drug Delivery. Molecules 2009, 14, 3286-3312.

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