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Molecules 2009, 14(9), 3286-3312; doi:10.3390/molecules14093286
Review

Squalene Emulsions for Parenteral Vaccine and Drug Delivery

Received: 13 August 2009; in revised form: 25 August 2009 / Accepted: 31 August 2009 / Published: 1 September 2009
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract: Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytica techniques for characterization of squalene emulsions are examined.
Keywords: squalene; squalane; adjuvant; emulsion; parenteral squalene; squalane; adjuvant; emulsion; parenteral
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fox, C.B. Squalene Emulsions for Parenteral Vaccine and Drug Delivery. Molecules 2009, 14, 3286-3312.

AMA Style

Fox CB. Squalene Emulsions for Parenteral Vaccine and Drug Delivery. Molecules. 2009; 14(9):3286-3312.

Chicago/Turabian Style

Fox, Christopher B. 2009. "Squalene Emulsions for Parenteral Vaccine and Drug Delivery." Molecules 14, no. 9: 3286-3312.


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