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Molecules 2009, 14(9), 3222-3228; doi:10.3390/molecules14093222
Article

Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using a Brønsted Acid Ionic Liquid as an Efficient Catalyst

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Received: 6 July 2009 / Revised: 20 August 2009 / Accepted: 24 August 2009 / Published: 27 August 2009
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Abstract

The Brønsted acid ionic liquid [PyN(CH2)4SO3H][p-CH3PhSO3] has been reported as an efficient catalyst for the Michael addition reaction of indoles to α,β-unsaturated ketones. Satisfactory results were obtained, with excellent yields and a simple experimental procedure. The catalyst could be recycled and reused up to three times without any noticeable decrease in the catalytic activity.
Keywords: Brønsted acid ionic liquid; β-indolylketones; Michael addition Brønsted acid ionic liquid; β-indolylketones; Michael addition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, C.-J.; Liu, C.-J. Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using a Brønsted Acid Ionic Liquid as an Efficient Catalyst. Molecules 2009, 14, 3222-3228.

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