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Molecules 2009, 14(8), 2780-2800; doi:10.3390/molecules14082780
Article

Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol®

, , , , ,  and *
Received: 17 June 2009 / Revised: 21 July 2009 / Accepted: 27 July 2009 / Published: 28 July 2009
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Abstract

Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol® have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative α-methylation of the resulting α,β-unsaturated ketones, and reduction of the corresponding β,γ-unsaturated ketones. The final compounds were evaluated organoleptically and one of them seemed to be of special interest for its natural sandalwood scent.
Keywords: sandalwood odorants; Polysantol® analogues; nopol derivative; odour evaluation sandalwood odorants; Polysantol® analogues; nopol derivative; odour evaluation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chapado, L.; Linares-Palomino, P.J.; Badía, C.; Salido, S.; Nogueras, M.; Sánchez, A.; Altarejos, J. Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol®. Molecules 2009, 14, 2780-2800.

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