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Molecules 2009, 14(8), 2780-2800; doi:10.3390/molecules14082780

Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol®

Departamento de Química Inorgánica y Orgánica, Facultad de Ciencias Experimentales, Universidad de Jaén, 23071 Jaén, Spain
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Received: 17 June 2009 / Revised: 21 July 2009 / Accepted: 27 July 2009 / Published: 28 July 2009
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Abstract

Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol® have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative α-methylation of the resulting α,β-unsaturated ketones, and reduction of the corresponding β,γ-unsaturated ketones. The final compounds were evaluated organoleptically and one of them seemed to be of special interest for its natural sandalwood scent.
Keywords: sandalwood odorants; Polysantol® analogues; nopol derivative; odour evaluation sandalwood odorants; Polysantol® analogues; nopol derivative; odour evaluation
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MDPI and ACS Style

Chapado, L.; Linares-Palomino, P.J.; Badía, C.; Salido, S.; Nogueras, M.; Sánchez, A.; Altarejos, J. Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol®. Molecules 2009, 14, 2780-2800.

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