Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines

doi:10.3390/molecules14062246

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Molecules 2009, 14(6), 2246-2253; doi:10.3390/molecules14062246

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Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines

Hai-Feng Chen ¹^,* , Guang-Hui Wang ¹ , Qiang Luo ¹ , Nai-Li Wang ² and Xin-Sheng Yao ²

¹ Institute for Biomedical Research, Xiamen University, Xiamen 361005, China ² Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China

* Author to whom correspondence should be addressed.

Received: 22 April 2009; in revised form: 25 May 2009 / Accepted: 16 June 2009 / Published: 19 June 2009

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Abstract: Two new steroidal saponins (1 and 2) were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated by the spectral data as 26-O-β-D-glucopyranosyl-5α-furost-25 (27)-ene-3β, 12β, 22, 26-tetraol-3-O-β-D-glucopyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-5β-furost-20 (22)-25 (27)-dien-3β, 12β, 26-triol-3-O-β-D-glucopyranosyl (1→2)-β-D-galactopyranoside (2), respectively. Their cytotoxic activities on several cancer cell lines (MCF-7, NCI-H460, SF-268 and HepG2) were tested. 1 showed special cytotoxity on SF-268, while 2 showed cytotoxity on NCI-H460 and SF-268 cell lines, respectively.

Keywords: Allium macrostemon Bunge; steroidal saponins; cytotoxic activity

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MDPI and ACS Style

Chen, H.-F.; Wang, G.-H.; Luo, Q.; Wang, N.-L.; Yao, X.-S. Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines. Molecules 2009, 14, 2246-2253.

AMA Style

Chen H.-F., Wang G.-H., Luo Q., Wang N.-L., Yao X.-S. Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines. Molecules. 2009; 14(6):2246-2253.

Chicago/Turabian Style

Chen, Hai-Feng; Wang, Guang-Hui; Luo, Qiang; Wang, Nai-Li; Yao, Xin-Sheng. 2009. "Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines." Molecules 14, no. 6: 2246-2253.

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