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Molecules 2009, 14(6), 2246-2253; doi:10.3390/molecules14062246
Article

Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines

1,* , 1
, 1
, 2
 and 2
1 Institute for Biomedical Research, Xiamen University, Xiamen 361005, China 2 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 22 April 2009 / Revised: 25 May 2009 / Accepted: 16 June 2009 / Published: 19 June 2009
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Abstract

Two new steroidal saponins (1 and 2) were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated by the spectral data as 26-O-β-D-glucopyranosyl-5α-furost-25 (27)-ene-3β, 12β, 22, 26-tetraol-3-O-β-D-glucopyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-5β-furost-20 (22)-25 (27)-dien-3β, 12β, 26-triol-3-O-β-D-glucopyranosyl (1→2)-β-D-galactopyranoside (2), respectively. Their cytotoxic activities on several cancer cell lines (MCF-7, NCI-H460, SF-268 and HepG2) were tested. 1 showed special cytotoxity on SF-268, while 2 showed cytotoxity on NCI-H460 and SF-268 cell lines, respectively.
Keywords: Allium macrostemon Bunge; steroidal saponins; cytotoxic activity Allium macrostemon Bunge; steroidal saponins; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, H.-F.; Wang, G.-H.; Luo, Q.; Wang, N.-L.; Yao, X.-S. Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines. Molecules 2009, 14, 2246-2253.

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