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Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Institute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
International University College of Nursing, B-27-6, Block B, Jaya One, No 72A Jalan Universiti, 46000 Petaling Jaya, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 17 March 2009; in revised form: 7 April 2009 / Accepted: 4 May 2009 / Published: 6 May 2009
Abstract: Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC50 value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.
Keywords: Pereskia bleo; Cactaceae; cytotoxic activity; cell lines
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Malek, S.N.A.; Shin, S.K.; Wahab, N.A.; Yaacob, H. Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves. Molecules 2009, 14, 1713-1724.
Malek SNA, Shin SK, Wahab NA, Yaacob H. Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves. Molecules. 2009; 14(5):1713-1724.
Malek, Sri Nurestri Abdul; Shin, Sim Kae; Wahab, Norhanom Abdul; Yaacob, Hashim. 2009. "Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves." Molecules 14, no. 5: 1713-1724.