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Molecules 2009, 14(5), 1713-1724; doi:10.3390/molecules14051713

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

1
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Institute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
3
International University College of Nursing, B-27-6, Block B, Jaya One, No 72A Jalan Universiti, 46000 Petaling Jaya, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Received: 17 March 2009 / Revised: 7 April 2009 / Accepted: 4 May 2009 / Published: 6 May 2009
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Abstract

Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC50 value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.
Keywords: Pereskia bleo; Cactaceae; cytotoxic activity; cell lines Pereskia bleo; Cactaceae; cytotoxic activity; cell lines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Malek, S.N.A.; Shin, S.K.; Wahab, N.A.; Yaacob, H. Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves. Molecules 2009, 14, 1713-1724.

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