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Molecules 2009, 14(5), 1652-1659; https://doi.org/10.3390/molecules14051652

A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt

Department of Applied Chemistry, Faculty of Science, Harbin Institute of Technology, PO Box 410#, Harbin 150001, P. R. China
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Received: 25 March 2009 / Revised: 10 April 2009 / Accepted: 15 April 2009 / Published: 27 April 2009
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Abstract

A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H2/Pd/C/C2H5OH system was developed. The products were characterized by TG, IR, 1H-NMR, 13C-NMR, HPLC and elemental analysis.
Keywords: 2; 3; 5; 6-Tetraaminopyridine; Nitration; Hydrogenation; Synthesis 2; 3; 5; 6-Tetraaminopyridine; Nitration; Hydrogenation; Synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wang, Y.; Hu, Z.; Meng, X.; Jing, J.; Song, Y.; Zhang, C.; Huang, Y. A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt. Molecules 2009, 14, 1652-1659.

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