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Molecules 2009, 14(5), 1652-1659; doi:10.3390/molecules14051652
Article

A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt

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Department of Applied Chemistry, Faculty of Science, Harbin Institute of Technology, PO Box 410#, Harbin 150001, P. R. China
* Author to whom correspondence should be addressed.
Received: 25 March 2009 / Revised: 10 April 2009 / Accepted: 15 April 2009 / Published: 27 April 2009
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Abstract

A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H2/Pd/C/C2H5OH system was developed. The products were characterized by TG, IR, 1H-NMR, 13C-NMR, HPLC and elemental analysis.
Keywords: 2; 3; 5; 6-Tetraaminopyridine; Nitration; Hydrogenation; Synthesis 2; 3; 5; 6-Tetraaminopyridine; Nitration; Hydrogenation; Synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, Y.; Hu, Z.; Meng, X.; Jing, J.; Song, Y.; Zhang, C.; Huang, Y. A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt. Molecules 2009, 14, 1652-1659.

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