Molecules 2009, 14(5), 1652-1659; doi:10.3390/molecules14051652
Article

A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt

Department of Applied Chemistry, Faculty of Science, Harbin Institute of Technology, PO Box 410#, Harbin 150001, P. R. China
* Author to whom correspondence should be addressed.
Received: 25 March 2009; in revised form: 10 April 2009 / Accepted: 15 April 2009 / Published: 27 April 2009
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Abstract: A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H2/Pd/C/C2H5OH system was developed. The products were characterized by TG, IR, 1H-NMR, 13C-NMR, HPLC and elemental analysis.
Keywords: 2; 3; 5; 6-Tetraaminopyridine; Nitration; Hydrogenation; Synthesis

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MDPI and ACS Style

Wang, Y.; Hu, Z.; Meng, X.; Jing, J.; Song, Y.; Zhang, C.; Huang, Y. A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt. Molecules 2009, 14, 1652-1659.

AMA Style

Wang Y, Hu Z, Meng X, Jing J, Song Y, Zhang C, Huang Y. A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt. Molecules. 2009; 14(5):1652-1659.

Chicago/Turabian Style

Wang, Yanhong; Hu, Zhen; Meng, Xiangli; Jing, Jiehui; Song, Yuanjun; Zhang, Chunhua; Huang, Yudong. 2009. "A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt." Molecules 14, no. 5: 1652-1659.

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