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Molecules 2009, 14(2), 868-883; doi:10.3390/molecules14020868
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

1, 2
,
1,* , 1, 2 and 1
1 College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124, P. R. China 2 Atmospheric Chemistry & Aerosol Research Department, Chinese Research Academy of Environmental Sciences, Beijing 100012, P. R. China
* Author to whom correspondence should be addressed.
Received: 30 December 2008 / Revised: 16 January 2009 / Accepted: 6 February 2009 / Published: 19 February 2009
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Abstract

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
Keywords: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1 integrase; Mg2+ binding; Aryl diketo acids 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1 integrase; Mg2+ binding; Aryl diketo acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xu, Y.-S.; Zeng, C.-C.; Jiao, Z.-G.; Hu, L.-M.; Zhong, R.-G. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives. Molecules 2009, 14, 868-883.

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