Molecules 2009, 14(2), 868-883; doi:10.3390/molecules14020868
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

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Received: 30 December 2008; in revised form: 16 January 2009 / Accepted: 6 February 2009 / Published: 19 February 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
Keywords: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1 integrase; Mg2+ binding; Aryl diketo acids
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MDPI and ACS Style

Xu, Y.-S.; Zeng, C.-C.; Jiao, Z.-G.; Hu, L.-M.; Zhong, R.-G. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives. Molecules 2009, 14, 868-883.

AMA Style

Xu Y-S, Zeng C-C, Jiao Z-G, Hu L-M, Zhong R-G. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives. Molecules. 2009; 14(2):868-883.

Chicago/Turabian Style

Xu, Yi-Sheng; Zeng, Cheng-Chu; Jiao, Zi-Guo; Hu, Li-Ming; Zhong, Ru-gang. 2009. "Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives." Molecules 14, no. 2: 868-883.

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