Molecules 2009, 14(2), 868-883; doi:10.3390/molecules14020868
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

Yi-Sheng Xu 1, 2 email, Cheng-Chu Zeng 1,* email, Zi-Guo Jiao 1 , Li-Ming Hu 2  and Ru-gang Zhong 1
1 College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124, P. R. China 2 Atmospheric Chemistry & Aerosol Research Department, Chinese Research Academy of Environmental Sciences, Beijing 100012, P. R. China
* Author to whom correspondence should be addressed.
Received: 30 December 2008; in revised form: 16 January 2009 / Accepted: 6 February 2009 / Published: 19 February 2009
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Abstract: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
Keywords: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1 integrase; Mg2+ binding; Aryl diketo acids

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Cite This Article

MDPI and ACS Style

Xu, Y.-S.; Zeng, C.-C.; Jiao, Z.-G.; Hu, L.-M.; Zhong, R.-G. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives. Molecules 2009, 14, 868-883.

AMA Style

Xu Y-S, Zeng C-C, Jiao Z-G, Hu L-M, Zhong R-G. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives. Molecules. 2009; 14(2):868-883.

Chicago/Turabian Style

Xu, Yi-Sheng; Zeng, Cheng-Chu; Jiao, Zi-Guo; Hu, Li-Ming; Zhong, Ru-gang. 2009. "Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives." Molecules 14, no. 2: 868-883.

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