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Molecules 2009, 14(2), 868-883; doi:10.3390/molecules14020868
Article

Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

1, 2
,
1,* , 1, 2 and 1
1 College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124, P. R. China 2 Atmospheric Chemistry & Aerosol Research Department, Chinese Research Academy of Environmental Sciences, Beijing 100012, P. R. China
* Author to whom correspondence should be addressed.
Received: 30 December 2008 / Revised: 16 January 2009 / Accepted: 6 February 2009 / Published: 19 February 2009
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Abstract

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
Keywords: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1 integrase; Mg2+ binding; Aryl diketo acids 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1 integrase; Mg2+ binding; Aryl diketo acids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xu, Y.-S.; Zeng, C.-C.; Jiao, Z.-G.; Hu, L.-M.; Zhong, R.-G. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives. Molecules 2009, 14, 868-883.

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