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Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers
Department of Chemistry, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia
Institute of Pharmacology, Faculty of Medicine, University of Pristina (Kosovska Mitrovica), Serbia
* Author to whom correspondence should be addressed.
Received: 12 November 2008; in revised form: 20 January 2009 / Accepted: 6 February 2009 / Published: 18 February 2009
Abstract: The aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat. The following parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione reductase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity. A battery of biochemical assays were used and the resulting data was statistically analyzed. Alcohol stress caused gastric ulcerations and hemorrhages and changed all the examined parameters except glutathione peroxidase activity. All drugs reduced the ulcer index and hemorrhages, with azithromycin showing the strongest effects. The drugs in combination with alcohol showed different effects on biochemical parameters. Our results indicate that the gastroprotective effects of the investigated drugs on experimental lesions induced by 100% ethanol could not be correlated with their antioxidative properties.
Keywords: Alcohol stress; Stomach; Bromocriptine; Haloperidol; Azithromycin; Antioxidative status
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Popovic, M.; Janicijevic-Hudomal, S.; Kaurinovic, B.; Rasic, J.; Trivic, S. Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers. Molecules 2009, 14, 816-826.
Popovic M, Janicijevic-Hudomal S, Kaurinovic B, Rasic J, Trivic S. Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers. Molecules. 2009; 14(2):816-826.
Popovic, Mira; Janicijevic-Hudomal, Snezana; Kaurinovic, Biljana; Rasic, Julijana; Trivic, Svetlana. 2009. "Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers." Molecules 14, no. 2: 816-826.