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Molecules 2009, 14(2), 798-806; doi:10.3390/molecules14020798
Article

Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines

1,* , 1, 2, 2 and 1
Received: 8 December 2008; in revised form: 8 January 2009 / Accepted: 10 February 2009 / Published: 16 February 2009
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Abstract: Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively. Compound 1 reacted with hydrazine hydrate in ethanol at room temperature to yield the dihydropyridazine 9 as a single product. In refluxing ethanol this product further reacted with hydrazine hydrate to yield the novel dihydropyrazolopyridazinamine 10.
Keywords: Aminopyrrole; Pyridazine; Pyrazolopyridazine; Phenacylmalononitrile Aminopyrrole; Pyridazine; Pyrazolopyridazine; Phenacylmalononitrile
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Mousawi, S.M.; Moustafa, M.S.; Meier, H.; Kolshorn, H.; Elnagdi, M.H. Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines. Molecules 2009, 14, 798-806.

AMA Style

Al-Mousawi SM, Moustafa MS, Meier H, Kolshorn H, Elnagdi MH. Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines. Molecules. 2009; 14(2):798-806.

Chicago/Turabian Style

Al-Mousawi, Saleh M.; Moustafa, Moustafa Sherief; Meier, Herbert; Kolshorn, Heinz; Elnagdi, Mohamed Hilmy. 2009. "Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines." Molecules 14, no. 2: 798-806.



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