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• Parlar, S
• Taşlı, H
• Erciyas, E
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• Parlar, S
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• Parlar, S
• Taşlı, H
• Erciyas, E

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Molecules 2009, 14(12), 5203-5215; doi:10.3390/molecules14125203

Article

Synthesis and Antimicrobial Activity of Some Pyridinium Salts

Vildan Alptüzün ^1,* , Sülünay Parlar ¹ , Hüseyin Taşlı ²  and Ercin Erciyas ¹

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, İzmir, Turkey ² Department of Microbiology, Faculty of Pharmacy, Ege University, 35100 Bornova, İzmir, Turkey

* Author to whom correspondence should be addressed.

Received: 16 November 2009; in revised form: 4 December 2009 / Accepted: 10 December 2009 / Published: 14 December 2009

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Abstract: Some substituted benzylidenehydrazinylpyridinium derivatives bearing benzyl, ethylphenyl and propylphenyl groups on the pyridinium nitrogen were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the microdilution method. Antimicrobial test results indicated that compounds containing a 3-phenylpropyl chain displayed the highest antimicrobial activity against Staphylococcus aureus and the compound 3d was the most active in the series against all tested bacteria and fungi strains.

Keywords: hydrazones; pyridinium salts; synthesis; antimicrobial activity

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