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Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand
* Author to whom correspondence should be addressed.
Received: 9 October 2009; in revised form: 23 November 2009 / Accepted: 27 November 2009 / Published: 1 December 2009
Abstract: Aqueous extracts from seeds of Areca catechu L. (Arecaceae) (AC) and nutgalls of Quercus infectoria Oliv. (Fagaceae) (QI) were investigated for their hepatoprotective potential by studying their antioxidant capacity using four different methods, by determining their in vitro anti−inflammatory activity against 5-lipoxygenase, and by evaluating their hepatoprotective potential against liver injury induced by carbon tetrachloride (CCl4) in rats. AC and QI extracts exhibited potent antioxidant and anti-inflammatory activities. Treatment of rats with AC and QI extracts reversed oxidative damage in hepatic tissues induced by CCl4. It is suggested that extracts rich in either condensed or hydrolysable tannins and known for their potent antioxidant and anti-inflammatory activities, may potentially confer protection against oxidative stress−induced liver injury. These data should contribute to evidence-based traditional medicines for anti-inflammatory and hepatoprotective effects of both extracts.
Keywords: anti-inflammatory; antioxidant; Areca catechu L.; hepatoprotective activity; Quercus infectoria Oliv
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MDPI and ACS Style
Pithayanukul, P.; Nithitanakool, S.; Bavovada, R. Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria. Molecules 2009, 14, 4987-5000.
Pithayanukul P, Nithitanakool S, Bavovada R. Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria. Molecules. 2009; 14(12):4987-5000.
Pithayanukul, Pimolpan; Nithitanakool, Saruth; Bavovada, Rapepol. 2009. "Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria." Molecules 14, no. 12: 4987-5000.