Molecules 2009, 14(12), 4915-4921; doi:10.3390/molecules14124915
Article

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Received: 26 October 2009; in revised form: 24 November 2009 / Accepted: 27 November 2009 / Published: 1 December 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators—pralidoxime, obidoxime and HI-6—which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime.
Keywords: acetylcholinesterase; butyrylcholinesterase; reactivator; nerve agent; oxime; pesticide; scavenger
PDF Full-text Download PDF Full-Text [59 KB, uploaded 18 June 2014 19:30 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Kuca, K.; Musilova, L.; Palecek, J.; Cirkva, V.; Paar, M.; Musilek, K.; Hrabinova, M.; Pohanka, M.; Karasova, J.Z.; Jun, D. Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules 2009, 14, 4915-4921.

AMA Style

Kuca K, Musilova L, Palecek J, Cirkva V, Paar M, Musilek K, Hrabinova M, Pohanka M, Karasova JZ, Jun D. Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules. 2009; 14(12):4915-4921.

Chicago/Turabian Style

Kuca, Kamil; Musilova, Lucie; Palecek, Jiri; Cirkva, Vladimir; Paar, Martin; Musilek, Kamil; Hrabinova, Martina; Pohanka, Miroslav; Karasova, Jana Zdarova; Jun, Daniel. 2009. "Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon." Molecules 14, no. 12: 4915-4921.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert