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Molecules 2009, 14(12), 4858-4865; doi:10.3390/molecules14124858

A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

Department of Applied Chemistry, China Agricultural University, 100193, Beijing, China
* Author to whom correspondence should be addressed.
Received: 21 October 2009 / Revised: 10 November 2009 / Accepted: 11 November 2009 / Published: 26 November 2009
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Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.
Keywords: thiazole; thiazoline; manganese dioxide; oxidation thiazole; thiazoline; manganese dioxide; oxidation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, Y.-B.; Chen, H.-L.; Wang, L.-Y.; Chen, X.-Z.; Fu, B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2. Molecules 2009, 14, 4858-4865.

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