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Molecules 2009, 14(12), 4858-4865; doi:10.3390/molecules14124858
Communication

A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

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*
Department of Applied Chemistry, China Agricultural University, 100193, Beijing, China
* Author to whom correspondence should be addressed.
Received: 21 October 2009 / Revised: 10 November 2009 / Accepted: 11 November 2009 / Published: 26 November 2009
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Abstract

Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.
Keywords: thiazole; thiazoline; manganese dioxide; oxidation thiazole; thiazoline; manganese dioxide; oxidation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yu, Y.-B.; Chen, H.-L.; Wang, L.-Y.; Chen, X.-Z.; Fu, B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2. Molecules 2009, 14, 4858-4865.

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