A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

doi:10.3390/molecules14124858

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Molecules 2009, 14(12), 4858-4865; doi:10.3390/molecules14124858

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A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO₂

Yan-Bo Yu, Hong-Liang Chen, Li-Yi Wang, Xin-Zheng Chen and Bin Fu*

Department of Applied Chemistry, China Agricultural University, 100193, Beijing, China

* Author to whom correspondence should be addressed.

Received: 21 October 2009; in revised form: 10 November 2009 / Accepted: 11 November 2009 / Published: 26 November 2009

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Abstract: Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO₂) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.

Keywords: thiazole; thiazoline; manganese dioxide; oxidation

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MDPI and ACS Style

Yu, Y.-B.; Chen, H.-L.; Wang, L.-Y.; Chen, X.-Z.; Fu, B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO₂. Molecules 2009, 14, 4858-4865.

AMA Style

Yu Y-B, Chen H-L, Wang L-Y, Chen X-Z, Fu B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO₂. Molecules. 2009; 14(12):4858-4865.

Chicago/Turabian Style

Yu, Yan-Bo; Chen, Hong-Liang; Wang, Li-Yi; Chen, Xin-Zheng; Fu, Bin. 2009. "A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO₂." Molecules 14, no. 12: 4858-4865.

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