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A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2
Department of Applied Chemistry, China Agricultural University, 100193, Beijing, China
* Author to whom correspondence should be addressed.
Received: 21 October 2009; in revised form: 10 November 2009 / Accepted: 11 November 2009 / Published: 26 November 2009
Abstract: Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.
Keywords: thiazole; thiazoline; manganese dioxide; oxidation
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Yu, Y.-B.; Chen, H.-L.; Wang, L.-Y.; Chen, X.-Z.; Fu, B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2. Molecules 2009, 14, 4858-4865.
Yu Y-B, Chen H-L, Wang L-Y, Chen X-Z, Fu B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2. Molecules. 2009; 14(12):4858-4865.
Yu, Yan-Bo; Chen, Hong-Liang; Wang, Li-Yi; Chen, Xin-Zheng; Fu, Bin. 2009. "A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2." Molecules 14, no. 12: 4858-4865.