Next Article in Journal
Synthesis, Structural Studies and Antitumoral Evaluation of C-6 Alkyl and Alkenyl Side Chain Pyrimidine Derivatives S
Previous Article in Journal
Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
Molecules 2009, 14(12), 4858-4865; doi:10.3390/molecules14124858
Communication

A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

,
,
,
 and
*
Received: 21 October 2009 / Revised: 10 November 2009 / Accepted: 11 November 2009 / Published: 26 November 2009
Download PDF [153 KB, uploaded 18 June 2014]

Abstract

Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.
Keywords: thiazole; thiazoline; manganese dioxide; oxidation thiazole; thiazoline; manganese dioxide; oxidation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Yu, Y.-B.; Chen, H.-L.; Wang, L.-Y.; Chen, X.-Z.; Fu, B. A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2. Molecules 2009, 14, 4858-4865.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert