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Molecules 2009, 14(10), 3844-3850; https://doi.org/10.3390/molecules14103844

Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis

1
Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, China
2
Institut de Chimie des Substances Naturelles, UPR2301, CNRS, 91198 Gif-sur-Yvette cedex, France
3
UMR 7206-USM 104 Eco-anthropologie et ethnobiologie, MNHN, 75231 Paris cedex, France
4
Department of Botany, Makerere University, Box 7062, Kampala, Uganda
5
Chemistry Department, Makerere University, Box 7062, Kampala, Uganda
*
Author to whom correspondence should be addressed.
Received: 28 August 2009 / Revised: 21 September 2009 / Accepted: 25 September 2009 / Published: 28 September 2009
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Abstract

One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
Keywords: Warburgia ugandensis; drimane-type sesquiterpenoid; ugandenial; cytotoxicity Warburgia ugandensis; drimane-type sesquiterpenoid; ugandenial; cytotoxicity
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Xu, M.; Litaudon, M.; Krief, S.; Martin, M.-T.; Kasenene, J.; Kiremire, B.; Dumontet, V.; Guéritte, F. Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis. Molecules 2009, 14, 3844-3850.

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