Abstract: One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
Keywords: Warburgia ugandensis; drimane-type sesquiterpenoid; ugandenial; cytotoxicity
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Xu, M.; Litaudon, M.; Krief, S.; Martin, M.-T.; Kasenene, J.; Kiremire, B.; Dumontet, V.; Guéritte, F. Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis. Molecules 2009, 14, 3844-3850.
Xu M, Litaudon M, Krief S, Martin M-T, Kasenene J, Kiremire B, Dumontet V, Guéritte F. Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis. Molecules. 2009; 14(10):3844-3850.
Xu, Min; Litaudon, Marc; Krief, Sabrina; Martin, Marie-Thérèse; Kasenene, John; Kiremire, Bernard; Dumontet, Vincent; Guéritte, Françoise. 2009. "Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis." Molecules 14, no. 10: 3844-3850.