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Molecules 2009, 14(10), 3844-3850; doi:10.3390/molecules14103844
Article

Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis

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Received: 28 August 2009 / Revised: 21 September 2009 / Accepted: 25 September 2009 / Published: 28 September 2009
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Abstract

One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
Keywords: Warburgia ugandensis; drimane-type sesquiterpenoid; ugandenial; cytotoxicity Warburgia ugandensis; drimane-type sesquiterpenoid; ugandenial; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xu, M.; Litaudon, M.; Krief, S.; Martin, M.-T.; Kasenene, J.; Kiremire, B.; Dumontet, V.; Guéritte, F. Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis. Molecules 2009, 14, 3844-3850.

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