Molecules 2008, 13(9), 2229-2237; doi:10.3390/molecules13092229
Article

New Triterpene Glucosides from the Roots of Rosa laevigata Michx

Jing-Quan Yuan 1,2 email, Xin-Zhou Yang 2 email, Jian-Hua Miao 1 email, Chun-Ping Tang 2 email, Chang-Qiang Ke 2 email, Ji-Bao Zhang 2 , Xiao-Jun Ma 1,3,* email and Yang Ye 2,* email
1 Guangxi Institute of Medicinal Plant, Nanning 530023, P.R. China 2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China 3 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, P.R. China
* Authors to whom correspondence should be addressed.
Received: 18 August 2008; in revised form: 11 September 2008 / Accepted: 12 September 2008 / Published: 22 September 2008
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Abstract: Two new ursane-type triterpene glucosides, 2α,3α,24-trihydroxyurs-12,18-dien-28-oic acid β-D-glucopyranosyl ester (1) and 2α,3α,23-trihydroxyurs-12,19(29)-dien-28-oic acid β-D-glucopyranosyl ester (2), were isolated from the roots of Rosa laevigata, together with three known compounds: 2α,3β,19α-trihydroxyurs-12-en-28-oic acid β-Dglucopyranosyl ester (3), 2α,3α,19α-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (4) and 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (5). The structures of new compounds were established on the basis of detailed 1D and 2D NMR spectroscopic analyses. Compounds 2 and 5 exhibited modest in vitro antifungal activities against Candida albicans and C. krusei.
Keywords: Ursane-type triterpene glucosides; Rosa laevigata; Antifungal activity

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Cite This Article

MDPI and ACS Style

Yuan, J.-Q.; Yang, X.-Z.; Miao, J.-H.; Tang, C.-P.; Ke, C.-Q.; Zhang, J.-B.; Ma, X.-J.; Ye, Y. New Triterpene Glucosides from the Roots of Rosa laevigata Michx. Molecules 2008, 13, 2229-2237.

AMA Style

Yuan J-Q, Yang X-Z, Miao J-H, Tang C-P, Ke C-Q, Zhang J-B, Ma X-J, Ye Y. New Triterpene Glucosides from the Roots of Rosa laevigata Michx. Molecules. 2008; 13(9):2229-2237.

Chicago/Turabian Style

Yuan, Jing-Quan; Yang, Xin-Zhou; Miao, Jian-Hua; Tang, Chun-Ping; Ke, Chang-Qiang; Zhang, Ji-Bao; Ma, Xiao-Jun; Ye, Yang. 2008. "New Triterpene Glucosides from the Roots of Rosa laevigata Michx." Molecules 13, no. 9: 2229-2237.

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