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New Triterpene Glucosides from the Roots of Rosa laevigata Michx
Guangxi Institute of Medicinal Plant, Nanning 530023, P.R. China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, P.R. China
* Authors to whom correspondence should be addressed.
Received: 18 August 2008; in revised form: 11 September 2008 / Accepted: 12 September 2008 / Published: 22 September 2008
Abstract: Two new ursane-type triterpene glucosides, 2α,3α,24-trihydroxyurs-12,18-dien-28-oic acid β-D-glucopyranosyl ester (1) and 2α,3α,23-trihydroxyurs-12,19(29)-dien-28-oic acid β-D-glucopyranosyl ester (2), were isolated from the roots of Rosa laevigata, together with three known compounds: 2α,3β,19α-trihydroxyurs-12-en-28-oic acid β-Dglucopyranosyl ester (3), 2α,3α,19α-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (4) and 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (5). The structures of new compounds were established on the basis of detailed 1D and 2D NMR spectroscopic analyses. Compounds 2 and 5 exhibited modest in vitro antifungal activities against Candida albicans and C. krusei.
Keywords: Ursane-type triterpene glucosides; Rosa laevigata; Antifungal activity
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Yuan, J.-Q.; Yang, X.-Z.; Miao, J.-H.; Tang, C.-P.; Ke, C.-Q.; Zhang, J.-B.; Ma, X.-J.; Ye, Y. New Triterpene Glucosides from the Roots of Rosa laevigata Michx. Molecules 2008, 13, 2229-2237.
Yuan J-Q, Yang X-Z, Miao J-H, Tang C-P, Ke C-Q, Zhang J-B, Ma X-J, Ye Y. New Triterpene Glucosides from the Roots of Rosa laevigata Michx. Molecules. 2008; 13(9):2229-2237.
Yuan, Jing-Quan; Yang, Xin-Zhou; Miao, Jian-Hua; Tang, Chun-Ping; Ke, Chang-Qiang; Zhang, Ji-Bao; Ma, Xiao-Jun; Ye, Yang. 2008. "New Triterpene Glucosides from the Roots of Rosa laevigata Michx." Molecules 13, no. 9: 2229-2237.