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Molecules 2008, 13(9), 2114-2125; doi:10.3390/molecules13092114
Communication

Chemical Composition, Antifungal and Antitumor Properties of Ether Extracts of Scapania verrucosa Heeg. and its Endophytic Fungus Chaetomium fusiforme

1, 1,2
,
1, 3
,
4 and 1,*
1 Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China 2 Academy of integrative medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China 3 Department of Biology, College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, P.R. China 4 Faculty of Science, School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, England, UK
* Author to whom correspondence should be addressed.
Received: 19 June 2008 / Revised: 15 August 2008 / Accepted: 3 September 2008 / Published: 4 September 2008
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Abstract

An endophytic fungus Chaetomium fusiforme was obtained from a liverwort, Scapania verrucosa. A comparison of the constituents of the ether extracts between S. verrucosa and the C. fusiforme culture was investigated by gas chromatography-mass spectrometry (GC/MS). The yield of ether extract based on dried plant material was 0.6% and 59 compounds were found in S. verrucosa. (+)-Aromadendrene (9.12%), hexadecanoic acid (6.92%), 6-isopropenyl-4,8a-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-2-ol (5.97%), s-tetrachloroethane (5.61%) and acetic acid (5.30%) were found to be the most abundant components among the 49 characterized compounds in S. verrucosa, which represented 84.64% of the total extract. However, the constituents of the cultured endophyte extract contained mainly acetic acid (35.05%), valeric acid, 3-methyl-, methyl ester (21.25%), and butane-2, 3-diol (12.24%). Although the extracts of S. verrucosa and its endophyte showed little chemical composition correlation, both of them demonstrated antifungal and antitumor activities. Furthermore, C. fusiforme has displayed a wider range of antimicrobial and antitumor activities, which were better than the host plant. These results could support the suggestion of endophytes as an alternative of the host for medicinal activity.
Keywords: Scapania verrucosa; Chaetomium fusiforme; GC/MS; antifungal activity; antitumor activity Scapania verrucosa; Chaetomium fusiforme; GC/MS; antifungal activity; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guo, L.; Wu, J.-Z.; Han, T.; Cao, T.; Rahman, K.; Qin, L.-P. Chemical Composition, Antifungal and Antitumor Properties of Ether Extracts of Scapania verrucosa Heeg. and its Endophytic Fungus Chaetomium fusiforme. Molecules 2008, 13, 2114-2125.

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