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New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora
College of Chemistry, Jilin University, Changchun 130062, P.R. China
College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P.R. China
Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
Chongqing Medical and Pharmaceutical College, Chongqing 400030, P.R. China
* Authors to whom correspondence should be addressed.
Received: 30 June 2008; in revised form: 27 August 2008 / Accepted: 28 August 2008 / Published: 1 September 2008
Abstract: Three new secoiridoid glycosides, named picrogentiosides A (1), B (2) and C (3), have been isolated from the underground parts of Picrorhiza Scrophulariiflora, together with the two known compounds plantamajoside (4) and plantainoside D (5). Their structures were established by spectroscopic analyses and comparisons with data from related compounds. A pilot pharmacological study showed that picrogentiosides A (1) and B (2) have an immunomodulatory effect in vitro.
Keywords: Picrorhiza scrophulariiflora; Secoiridoid glycosides; Picrogentiosides A; B and C; Immunoenhancement
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MDPI and ACS Style
Zou, L.-C.; Zhu, T.-F.; Xiang, H.; Yu, L.; Yan, Z.-H.; Gan, S.-C.; Wang, D.-C.; Zeng, S.; Deng, X.-M. New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora. Molecules 2008, 13, 2049-2057.
Zou L-C, Zhu T-F, Xiang H, Yu L, Yan Z-H, Gan S-C, Wang D-C, Zeng S, Deng X-M. New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora. Molecules. 2008; 13(9):2049-2057.
Zou, Lian-Chun; Zhu, Tong-Fei; Xiang, Hua; Yu, Lu; Yan, Zhi-Hui; Gan, Shu-Cai; Wang, Da-Cheng; Zeng, Sheng; Deng, Xu-Ming. 2008. "New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora." Molecules 13, no. 9: 2049-2057.