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Molecules 2008, 13(4), 818-830; doi:10.3390/molecules13040818
Article

Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst

1
, 2
 and 1,2,*
Received: 26 March 2008; in revised form: 8 April 2008 / Accepted: 8 April 2007 / Published: 9 April 2008
Download PDF [128 KB, uploaded 18 June 2014]
Abstract: New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing toluene under a nitrogen atmosphere. The target N-aryl derivativeswere obtained in moderate to good yields ranging from 27% to 82%. The proceduredescribed could be widely employed for the preparation of new heterocyclic compounds.The structures of the new compounds were confirmed by FT-NMR, FT-IR and elementalanalysis.
Keywords: Palladium catalyst; N-arylation; aminopyrimidine; xantphos; Suzuki coupling; Buchwald-Hartwig amination. Palladium catalyst; N-arylation; aminopyrimidine; xantphos; Suzuki coupling; Buchwald-Hartwig amination.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

El-Deeb, I.M.; Ryu, J.C.; Lee, S.H. Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst. Molecules 2008, 13, 818-830.

AMA Style

El-Deeb IM, Ryu JC, Lee SH. Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst. Molecules. 2008; 13(4):818-830.

Chicago/Turabian Style

El-Deeb, Ibrahim M.; Ryu, Jae C.; Lee, So H. 2008. "Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst." Molecules 13, no. 4: 818-830.


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