Molecules 2008, 13(4), 818-830; doi:10.3390/molecules13040818
Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst
1
Department of Biomolecular Science, University of Science and Technology, Daejon, Korea
2
Life Sciences Research Division, Korea Institute of Science & Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
*
Author to whom correspondence should be addressed.
Received: 26 March 2008 / Revised: 8 April 2008 / Accepted: 8 April 2007 / Published: 9 April 2008
Abstract
New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing toluene under a nitrogen atmosphere. The target N-aryl derivativeswere obtained in moderate to good yields ranging from 27% to 82%. The proceduredescribed could be widely employed for the preparation of new heterocyclic compounds.The structures of the new compounds were confirmed by FT-NMR, FT-IR and elementalanalysis. View Full-TextKeywords:
Palladium catalyst; N-arylation; aminopyrimidine; xantphos; Suzuki coupling; Buchwald-Hartwig amination.
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
Scifeed alert for new publications
Never miss any articles matching your research from any publisher- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Share & Cite This Article
MDPI and ACS Style
El-Deeb, I.M.; Ryu, J.C.; Lee, S.H. Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst. Molecules 2008, 13, 818-830.
Related Articles
Article Metrics
Comments
Molecules
EISSN 1420-3049
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert