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Molecules 2008, 13(12), 3140-3148; doi:10.3390/molecules13123140
Article

Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles

1,2
, 2,*  and 2
Received: 5 September 2008; in revised form: 27 September 2008 / Accepted: 5 November 2008 / Published: 15 December 2008
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Abstract: Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively.
Keywords: β-Oxoalkanonitriles; 3-Pyrazolylamine; 3-Isoxazolylamine; Phenacyl bromide; Ethyl cyanoacetate β-Oxoalkanonitriles; 3-Pyrazolylamine; 3-Isoxazolylamine; Phenacyl bromide; Ethyl cyanoacetate
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MDPI and ACS Style

Riyadh, S.M.; Al-Matar, H.M.; Elnagdi, M.H. Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles. Molecules 2008, 13, 3140-3148.

AMA Style

Riyadh SM, Al-Matar HM, Elnagdi MH. Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles. Molecules. 2008; 13(12):3140-3148.

Chicago/Turabian Style

Riyadh, Sayed M.; Al-Matar, Hamad M.; Elnagdi, Mohamed H. 2008. "Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles." Molecules 13, no. 12: 3140-3148.



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