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Molecules 2008, 13(11), 2837-2847; doi:10.3390/molecules131102837

Microwave Accelerated Aza-Claisen Rearrangement

Institute of Chemical Sciences, Department of Organic Chemistry, P. J. Šafárik University, Moyzesova 11, SK-040 01 Košice, Slovak Republic
Author to whom correspondence should be addressed.
Received: 7 October 2008 / Revised: 28 October 2008 / Accepted: 4 November 2008 / Published: 14 November 2008
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A study of microwave-induced and standard thermal Overman rearrangement of selected allylic trichloroacetimidates 1a-1f, 6-8 to the corresponding acetamides 2a-2f, 9-11 is reported. The microwave-assisted rearrangement of trifluoroacetimidate 13 is also described. Using this methodology, an efficient access to versatile allylic trihaloacetamides building synthons was established.
Keywords: Overman rearrangement; Imidate; Microwave irradiation Overman rearrangement; Imidate; Microwave irradiation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gajdošíková, E.; Martinková, M.; Gonda, J.; Conka, P. Microwave Accelerated Aza-Claisen Rearrangement. Molecules 2008, 13, 2837-2847.

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