Molecules 2008, 13(11), 2750-2757; doi:10.3390/molecules13112750
Article

Synthesis with Nitriles: Synthesis of Some New Mercaptopyridazine, Mercaptopyridazino[1,6-a]quinazoline and Thiophene Derivatives

email
Received: 17 July 2008; in revised form: 20 October 2008 / Accepted: 28 October 2008 / Published: 4 November 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 2-(1-(4-Bromophenyl)-2-thiocyanatoethylidene)malononitrile (3) undergoes azo coupling with diazotized aromatic amines to afford arylhydrazone derivatives, which are readily cyclized to afford the corresponding 3(2H)-pyridazinimine derivatives upon reflux in aqueous NaOH. Under similar condition an o-cyanoarylhydrazone derivative was cyclized into 6H-pyridazino[1,6-a]quinazolin-6-imine, which in turn was easily transformed into 6H-pyridazino[1,6-a]quinazolin-6-one on reflux in ethanolic/HCl. Compound 3 afforded substituted 5-acetylthiophene derivatives upon reflux in AcOH/HCl mixtures.
Keywords: Thiophene; Pyridazine; Pyridazino[1; 6-a]quinazoline
PDF Full-text Download PDF Full-Text [229 KB, uploaded 18 June 2014 19:28 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Al-Sheikh, M.A. Synthesis with Nitriles: Synthesis of Some New Mercaptopyridazine, Mercaptopyridazino[1,6-a]quinazoline and Thiophene Derivatives. Molecules 2008, 13, 2750-2757.

AMA Style

Al-Sheikh MA. Synthesis with Nitriles: Synthesis of Some New Mercaptopyridazine, Mercaptopyridazino[1,6-a]quinazoline and Thiophene Derivatives. Molecules. 2008; 13(11):2750-2757.

Chicago/Turabian Style

Al-Sheikh, Mariam A. 2008. "Synthesis with Nitriles: Synthesis of Some New Mercaptopyridazine, Mercaptopyridazino[1,6-a]quinazoline and Thiophene Derivatives." Molecules 13, no. 11: 2750-2757.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert