Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents

doi:10.3390/12081771

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Molecules 2007, 12(8), 1771-1795; doi:10.3390/12081771

Review

Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents

Elena Pérez-Mayoral¹, Jordi Soler-Padrós¹, Viviana Negri¹, Sebastián Cerdán³ and Paloma Ballesteros^1,*

¹ Laboratorio de Síntesis Orgánica e Imagen Molecular por Resonancia Magnética, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain ² Departamento de Química Inorgánica y Química Técnica, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain ³ Laboratorio de Imagen Espectroscópica por Resonancia Magnética (LIERM), Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, C/ Arturo Duperier 4, E-28029 Madrid, Spain

* Author to whom correspondence should be addressed.

Received: 29 May 2007; in revised form: 3 August 2007 / Accepted: 3 August 2007 / Published: 9 August 2007

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Abstract: Magnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable of more precisely delineating the borderline regions. In the present review we focus on the synthetic strategies used to obtain MRI CAs containing heterocyclic rings.

Keywords: Lanthanide Complexes; Contrast Agents; Heterocyclic Ligands; MR Imaging

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MDPI and ACS Style

Pérez-Mayoral, E.; Soler-Padrós, J.; Negri, V.; Cerdán, S.; Ballesteros, P. Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents. Molecules 2007, 12, 1771-1795.

AMA Style

Pérez-Mayoral E, Soler-Padrós J, Negri V, Cerdán S, Ballesteros P. Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents. Molecules. 2007; 12(8):1771-1795.

Chicago/Turabian Style

Pérez-Mayoral, Elena; Soler-Padrós, Jordi; Negri, Viviana; Cerdán, Sebastián; Ballesteros, Paloma. 2007. "Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents." Molecules 12, no. 8: 1771-1795.

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