Molecules 2007, 12(8), 1771-1795; doi:10.3390/12081771
Review

Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents

1 Laboratorio de Síntesis Orgánica e Imagen Molecular por Resonancia Magnética, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain 2 Departamento de Química Inorgánica y Química Técnica, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain 3 Laboratorio de Imagen Espectroscópica por Resonancia Magnética (LIERM), Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, C/ Arturo Duperier 4, E-28029 Madrid, Spain
* Author to whom correspondence should be addressed.
Received: 29 May 2007; in revised form: 3 August 2007 / Accepted: 3 August 2007 / Published: 9 August 2007
PDF Full-text Download PDF Full-Text [184 KB, uploaded 2 October 2008 11:53 CEST]
Abstract: Magnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable of more precisely delineating the borderline regions. In the present review we focus on the synthetic strategies used to obtain MRI CAs containing heterocyclic rings.
Keywords: Lanthanide Complexes; Contrast Agents; Heterocyclic Ligands; MR Imaging

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Pérez-Mayoral, E.; Soler-Padrós, J.; Negri, V.; Cerdán, S.; Ballesteros, P. Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents. Molecules 2007, 12, 1771-1795.

AMA Style

Pérez-Mayoral E, Soler-Padrós J, Negri V, Cerdán S, Ballesteros P. Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents. Molecules. 2007; 12(8):1771-1795.

Chicago/Turabian Style

Pérez-Mayoral, Elena; Soler-Padrós, Jordi; Negri, Viviana; Cerdán, Sebastián; Ballesteros, Paloma. 2007. "Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents." Molecules 12, no. 8: 1771-1795.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert