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Molecules 2007, 12(7), 1334-1340; doi:10.3390/12071334
Article

A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1

,  and *
Process Technology Development Division, Defence R and D Establishment, Jhansi Road, Gwalior 474002 (MP) India
* Author to whom correspondence should be addressed.
Received: 16 April 2007 / Revised: 16 May 2007 / Accepted: 16 July 2007 / Published: 9 July 2007
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Abstract

A novel and efficient method for the synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes (4) using activated silica as dehydrating agent has been developed. The reaction involves the condensation of substituted diacetyl monoxime and N,N-dialkylaminoisopropyl-phosphono hydrazide or O-alkylisopropylphosphono hydrazides and gave the corresponding analogues of a naturally occurring fish toxin in excellent yields under mild conditions.
Keywords: Hydrazides; diacetyl monoxime; marine fish toxin; phosphonohydrazido oxime Hydrazides; diacetyl monoxime; marine fish toxin; phosphonohydrazido oxime
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kumar, R.; Gupta, A.K.; Kaushik, M.P. A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1. Molecules 2007, 12, 1334-1340.

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