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Molecules 2007, 12(4), 832-841; doi:10.3390/12040832
Article

Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

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Received: 30 January 2007; in revised form: 2 April 2007 / Accepted: 3 April 2007 / Published: 23 April 2007
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Abstract: Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-28(13)- lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.
Keywords: Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, L.; Liu, Z.-H.; Tian, J.-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules 2007, 12, 832-841.

AMA Style

Zhang L, Liu Z-H, Tian J-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules. 2007; 12(4):832-841.

Chicago/Turabian Style

Zhang, Lin; Liu, Zhen-Huan; Tian, Jing-Kui. 2007. "Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum." Molecules 12, no. 4: 832-841.


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