Next Article in Journal
Identificationof Major Phenolic Compounds of Chinese Water Chestnut and their Antioxidant Activity
Previous Article in Journal
Different Supramolecular Coordination Polymers of [N,N'-di(pyrazin-2-yl)-pyridine-2,6-diamine]Ni(II) with Anions and Solvent Molecules as a Result of Hydrogen Bonding
Molecules 2007, 12(4), 832-841; doi:10.3390/12040832

Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

 and *
Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China
* Author to whom correspondence should be addressed.
Received: 30 January 2007 / Revised: 2 April 2007 / Accepted: 3 April 2007 / Published: 23 April 2007
View Full-Text   |   Download PDF [103 KB, uploaded 18 June 2014]   |   Browse Figures


Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-28(13)- lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.
Keywords: Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Zhang, L.; Liu, Z.-H.; Tian, J.-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules 2007, 12, 832-841.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert