Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

doi:10.3390/12040832

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Molecules 2007, 12(4), 832-841; doi:10.3390/12040832

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Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

Lin Zhang, Zhen-Huan Liu and Jing-Kui Tian*

Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

* Author to whom correspondence should be addressed.

Received: 30 January 2007; in revised form: 2 April 2007 / Accepted: 3 April 2007 / Published: 23 April 2007

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Abstract: Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-28(13)- lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.

Keywords: Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity

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MDPI and ACS Style

Zhang, L.; Liu, Z.-H.; Tian, J.-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules 2007, 12, 832-841.

AMA Style

Zhang L, Liu Z-H, Tian J-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules. 2007; 12(4):832-841.

Chicago/Turabian Style

Zhang, Lin; Liu, Zhen-Huan; Tian, Jing-Kui. 2007. "Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum." Molecules 12, no. 4: 832-841.

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