Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

doi:10.3390/12030297

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Molecules 2007, 12(3), 297-303; doi:10.3390/12030297

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Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

Jian-yu Jin ¹, Li-xue Zhang ²^,* , Xian-xing Chen ³, An-jiang Zhang ² and Hai-le Zhang ⁴

¹ College of Education, Wenzhou University, Wenzhou 325035, P.R. China
² College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P.R. China
³ College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325027, P.R. China
⁴ Department of Molecular Biology & Chemistry, Scripps Research Institute, San Diego, CA 92037, USA

^* Author to whom correspondence should be addressed.

Received: 12 February 2007; in revised form: 27 February 2007 / Accepted: 28 February 2007 / Published: 3 March 2007

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Abstract: A series of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]-thia-diazines were synthesized by the reaction of 4-amino-3-(3-hydroxypropyl)-5-mercapto-1,2,4-triazole (1) with substituted ω-haloacetophenones. Their structures were confirmed by elemental analysis, IR, 1H-NMR, and 13C-NMR. Tests of plant growth regulating effects showed that the title compounds display remarkable inhibitory activities on the growth of radish and wheat.

Keywords: Hydroxyl groups; 1; 2; 4-triazolo[3; 4-b]-1; 3; 4-thiadiazine; NMR; plant growth regulation

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MDPI and ACS Style

Jin, J.-Y.; Zhang, L.-X.; Chen, X.-X.; Zhang, A.-J.; Zhang, H.-L. Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines. Molecules 2007, 12, 297-303.

AMA Style

Jin J.-Y., Zhang L.-X., Chen X.-X., Zhang A.-J., Zhang H.-L. Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines. Molecules. 2007; 12(3):297-303.

Chicago/Turabian Style

Jin, Jian-yu; Zhang, Li-xue; Chen, Xian-xing; Zhang, An-jiang; Zhang, Hai-le. 2007. "Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines." Molecules 12, no. 3: 297-303.

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