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Molecules 2007, 12(3), 297-303; doi:10.3390/12030297
Article

Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

1, 2,* , 3, 2 and 4
1 College of Education, Wenzhou University, Wenzhou 325035, P.R. China 2 College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P.R. China 3 College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325027, P.R. China 4 Department of Molecular Biology & Chemistry, Scripps Research Institute, San Diego, CA 92037, USA
* Author to whom correspondence should be addressed.
Received: 12 February 2007 / Revised: 27 February 2007 / Accepted: 28 February 2007 / Published: 3 March 2007
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Abstract

A series of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]-thia-diazines were synthesized by the reaction of 4-amino-3-(3-hydroxypropyl)-5-mercapto-1,2,4-triazole (1) with substituted ω-haloacetophenones. Their structures were confirmed by elemental analysis, IR, 1H-NMR, and 13C-NMR. Tests of plant growth regulating effects showed that the title compounds display remarkable inhibitory activities on the growth of radish and wheat.
Keywords: Hydroxyl groups; 1; 2; 4-triazolo[3; 4-b]-1; 3; 4-thiadiazine; NMR; plant growth regulation Hydroxyl groups; 1; 2; 4-triazolo[3; 4-b]-1; 3; 4-thiadiazine; NMR; plant growth regulation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Jin, J.-Y.; Zhang, L.-X.; Chen, X.-X.; Zhang, A.-J.; Zhang, H.-L. Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines. Molecules 2007, 12, 297-303.

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