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Molecules 2007, 12(3), 297-303; doi:10.3390/12030297
Article

Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

1, 2,* , 3, 2 and 4
1 College of Education, Wenzhou University, Wenzhou 325035, P.R. China 2 College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P.R. China 3 College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325027, P.R. China 4 Department of Molecular Biology & Chemistry, Scripps Research Institute, San Diego, CA 92037, USA
* Author to whom correspondence should be addressed.
Received: 12 February 2007 / Revised: 27 February 2007 / Accepted: 28 February 2007 / Published: 3 March 2007
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Abstract

A series of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]-thia-diazines were synthesized by the reaction of 4-amino-3-(3-hydroxypropyl)-5-mercapto-1,2,4-triazole (1) with substituted ω-haloacetophenones. Their structures were confirmed by elemental analysis, IR, 1H-NMR, and 13C-NMR. Tests of plant growth regulating effects showed that the title compounds display remarkable inhibitory activities on the growth of radish and wheat.
Keywords: Hydroxyl groups; 1; 2; 4-triazolo[3; 4-b]-1; 3; 4-thiadiazine; NMR; plant growth regulation Hydroxyl groups; 1; 2; 4-triazolo[3; 4-b]-1; 3; 4-thiadiazine; NMR; plant growth regulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jin, J.-Y.; Zhang, L.-X.; Chen, X.-X.; Zhang, A.-J.; Zhang, H.-L. Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines. Molecules 2007, 12, 297-303.

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