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Molecules 2007, 12(11), 2434-2449; doi:10.3390/12112434
Article

Dopamine-Imprinted Polymers: Template-Monomer Interactions, Analysis of Template Removal and Application to Solid Phase Extraction

1, 1,* , 2 and 2
Received: 21 August 2007 / Revised: 9 October 2007 / Accepted: 21 October 2007 / Published: 1 November 2007
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Abstract

A dopamine-imprinted polymer (MIP) was prepared in aqueous methanolsolution at 60oC by free-radical cross-linking polymerization of methacrylic acid in thepresence of ethylene glycol dimethacrylate as the cross-linker and dopamine hydrochlorideas the template molecule. Its ability to isolate dopamine was evaluated as the basis of asolid phase extraction procedure and compared with that of a non-imprinted polymer(NIP). The binding of dopamine was 84.1% and 29.1% for MIP and NIP, respectively.Various reported post-polymerization treatments to reduce template bleeding wereexamined. In our case the lowest bleeding was achieved after applying a combinedprocedure: continuous extraction in a Soxhlet apparatus (CE), followed by microwave-assisted extraction (ME) to a level of 0.061 μg/mL. A simplified model of the template-monomer complexes allowed rationalization of monomer choice based on the heats ofcomplex formation at a PM3 level of theory.
Keywords: Dopamine hydrochloride isolation; theoretical binding energy; molecularly imprinted polymer; template removal; solid phase extraction Dopamine hydrochloride isolation; theoretical binding energy; molecularly imprinted polymer; template removal; solid phase extraction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Luliński, P.; Maciejewska, D.; Bamburowicz-Klimkowska, M.; Szutowski, M. Dopamine-Imprinted Polymers: Template-Monomer Interactions, Analysis of Template Removal and Application to Solid Phase Extraction. Molecules 2007, 12, 2434-2449.

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