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Molecules 2007, 12(10), 2413-2426; doi:10.3390/12102413

Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies

1
Department of Chemistry, North Bengal University, Raja Rammohunpur, Siliguri, 734013, WB, India
2
Himalayan Pharmacy Institute, Majhitar, P.O.Rangpo, E.Sikkim, 737132, India
3
Department of Biotechnology, North Bengal University, Raja Rammohunpur, Siliguri, 734013, WB, India
*
Author to whom correspondence should be addressed.
Received: 7 August 2007 / Revised: 9 October 2007 / Accepted: 9 October 2007 / Published: 30 October 2007
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Abstract

Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett’s sigma constants and the substituent’s molar refractivity. View Full-Text
Keywords: 2-Phenylquinazoline-4(3H)-one; antibacterial activities; QSAR; quinazolones. 2-Phenylquinazoline-4(3H)-one; antibacterial activities; QSAR; quinazolones.
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MDPI and ACS Style

Nanda, A.K.; Ganguli, S.; Chakraborty, R. Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies. Molecules 2007, 12, 2413-2426.

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