Molecules 2007, 12(10), 2413-2426; doi:10.3390/12102413
Article

Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies

1,* email, 2email and 3email
Received: 7 August 2007; in revised form: 9 October 2007 / Accepted: 9 October 2007 / Published: 30 October 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett’s sigma constants and the substituent’s molar refractivity.
Keywords: 2-Phenylquinazoline-4(3H)-one; antibacterial activities; QSAR; quinazolones.
PDF Full-text Download PDF Full-Text [161 KB, uploaded 18 June 2014 19:27 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Nanda, A.K.; Ganguli, S.; Chakraborty, R. Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies. Molecules 2007, 12, 2413-2426.

AMA Style

Nanda AK, Ganguli S, Chakraborty R. Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies. Molecules. 2007; 12(10):2413-2426.

Chicago/Turabian Style

Nanda, Ashis K.; Ganguli, Subarna; Chakraborty, Ranadhir. 2007. "Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies." Molecules 12, no. 10: 2413-2426.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert