Next Article in Journal
A Simple and Efficient Approach to the Synthesis of Endo and Exo Bicyclo[6.1.0]nona-3,5-diene-9-carboxaldehyde
Previous Article in Journal
Bioreversible Derivatives of Phenol. 2. Reactivity of Carbonate Esters with Fatty Acid-like Structures Towards Hydrolysis in Aqueous Solutions
Molecules 2007, 12(10), 2413-2426; doi:10.3390/12102413
Article

Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies

1,* , 2
 and
3
1 Department of Chemistry, North Bengal University, Raja Rammohunpur, Siliguri, 734013, WB, India 2 Himalayan Pharmacy Institute, Majhitar, P.O.Rangpo, E.Sikkim, 737132, India 3 Department of Biotechnology, North Bengal University, Raja Rammohunpur, Siliguri, 734013, WB, India
* Author to whom correspondence should be addressed.
Received: 7 August 2007 / Revised: 9 October 2007 / Accepted: 9 October 2007 / Published: 30 October 2007
Download PDF [161 KB, uploaded 18 June 2014]

Abstract

Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett’s sigma constants and the substituent’s molar refractivity.
Keywords: 2-Phenylquinazoline-4(3H)-one; antibacterial activities; QSAR; quinazolones. 2-Phenylquinazoline-4(3H)-one; antibacterial activities; QSAR; quinazolones.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Nanda, A.K.; Ganguli, S.; Chakraborty, R. Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies. Molecules 2007, 12, 2413-2426.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert